生物活性玻璃修饰的3d打印磺化聚醚酮多孔骨修复支架。

IF 3.5 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology and Bioengineering Pub Date : 2025-06-25 DOI:10.1002/bit.70000

Xia Sheng,Zhenxu Wu,Xinyu Li,Qingming Ji,Xue Wang

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引用次数: 0

摘要

聚醚醚酮（PEEK）基质的生物惰性特性决定了PEEK支架在骨再生中不能显示生物活性。结合PEEK优异的机械强度和生物活性玻璃（BAG）的生物活性的支架非常适合骨科应用。在本研究中，采用熔融沉积建模（FDM） 3D打印方法设计并制造了PEEK支架的多孔结构。采用新型化学液相沉积（CLD）方法，将BAG作为覆盖磺化PEEK （SPEEK）表面的涂层材料。改性后的支架具有孔隙结构和粗糙的表面，促进了支架上的矿化。此外，该支架还表现出出色的细胞相容性和骨活性。此外，一项在兔子身上进行的骨缺损修复研究显示，新的骨组织从支架边缘向中心生长。植入4周后，骨缺损区与宿主骨端完全连接。综上所述，SPEEK-BAG支架在骨修复方面具有广阔的应用前景。

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3D-Printed Sulfonated Polyetheretherketone Porous Scaffold Modified by Bioactive Glass for Bone Repair.

The bioinert characteristics of the polyetheretherketone (PEEK) matrix determine that the PEEK scaffolds cannot display bioactivity in bone regeneration. Scaffolds that combine the excellent mechanical strength of PEEK with the bioactivity of bioactive glass (BAG) are highly desirable for orthopedic applications. In this study, the porous structure of a PEEK scaffold was designed and fabricated via the fused deposition modeling (FDM) 3D printing method. The BAG was used as a coating material to cover the surface of sulfonated PEEK (SPEEK) via a novel chemical liquid deposition (CLD) method. The modified scaffold with a pore structure and rough surface promoted the mineralization on the scaffold. Additionally, the scaffold showed outstanding cytocompatibility and osteoactivity. Moreover, a bone defect repair study in rabbits revealed that the new bone tissues grew into the scaffold from the margin toward the center. The bone defect region was completely connected to the host bone end after 4 weeks of implantation. In summary, the SPEEK-BAG scaffold has promising potential for bone repair applications.

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来源期刊

Biotechnology and Bioengineering 工程技术-生物工程与应用微生物

CiteScore

7.90

自引率

5.30%

发文量

280

审稿时长

2.1 months

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