Wasim Aluísio Prates-Syed, Aline Aparecida Lima, Nelson Cortes, Evelyn Carvalho, Jaqueline Dinis Queiroz Silva, Bárbara Hamaguchi, Ricardo Durães-Carvalho, Otávio Cabral-Marques, Thomas Hagan, José E Krieger, Gustavo Cabral-Miranda
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VaxGO: an interactive web tool for systems vaccinology data analysis.
Motivation: RNA sequencing is crucial for investigating transcriptional patterns in immunology and vaccine research. However, the analysis of RNA sequencing data often requires programming skills, which can limit accessibility for researchers lacking such expertise.
Results: We present VaxGO, an intuitive web-based tool designed to facilitate the analysis of differentially expressed genes in the context of immune processes and cells during vaccination. This tool integrates data from Gene Ontology, CellMarker 2.0, the MSigDB Vax collection, and other key studies, including transcriptional atlases of vaccines against COVID-19 and other diseases. VaxGO is an interactive, web-based tool, offering a user-friendly platform for exploring immune responses and vaccine efficacy without programming expertise.
Availability and implementation: The VaxGO tool is available at https://github.com/wapsyed/VaxGO.
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