Yasaman Safarkhanlo, Jérôme Yerly, Mariana B L Falcão, Adèle L C Mackowiak, Davide Piccini, Matthias Stuber, Bernd Jung, Christoph Gräni, Jessica A M Bastiaansen
{"title":"快速中断稳态（FISS）和快速水激发脉冲在1.5 T自由运行全心MRI中脂肪信号抑制的比较。","authors":"Yasaman Safarkhanlo, Jérôme Yerly, Mariana B L Falcão, Adèle L C Mackowiak, Davide Piccini, Matthias Stuber, Bernd Jung, Christoph Gräni, Jessica A M Bastiaansen","doi":"10.1007/s10334-025-01273-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Free-running whole-heart MRI using balanced steady-state free precession (bSSFP) sequences offer high SNR and myocardial tissue contrast. However, an inadequate fat signal suppression may introduce artifacts and is particularly challenging with non-Cartesian readouts. The aim of this study was to evaluate different fat-signal suppression methods for whole-heart free-running MRI at 1.5 T using numerical simulations, phantom, and cardiac MRI experiments without the use of contrast agents.</p><p><strong>Methods: </strong>Binomial off-resonant rectangular (BORR), lipid insensitive binomial off-resonant RF excitation (LIBRE), and lipid insensitive binomial off-resonant (LIBOR) pulses were implemented within a 3D radial bSSFP sequence. Their pulse parameters were optimized for fat signal suppression at 1.5 T using simulations and phantom experiments. Optimized protocols, along with a free-running fast interrupted steady-state (FISS) and non-fat suppressed bSSFP sequence, were used to acquire phantom and cardiac data in five volunteers. SAR values were recorded. The SNR and CNR<sub>Water-Fat</sub> were measured in phantom data, while SNR and CNR<sub>Blood-Myocardium</sub> were quantified in volunteers using reconstruction without motion correction. Motion-resolved reconstructions were used for qualitative assessments. Statistical differences were analyzed using one-way ANOVA.</p><p><strong>Results: </strong>LIBOR had the highest CNR<sub>Water-Fat</sub> (276.8 ± 2.5) in phantoms, followed by LIBRE (268.1 ± 2.6), BORR (249.9 ± 2.2), and FISS (212.7 ± 2.7), though these differences were not statistically significant (p > 0.05). In volunteers, BORR had the highest SNR in the ventricular blood pool (17.0 ± 1.5), and LIBRE had the highest CNR<sub>Blood-Fat</sub> (29.4 ± 9.3). FISS had the highest CNR<sub>Blood-Myocardium</sub> (29.0 ± 8.9), but the differences were not significant (p > 0.05). Motion-resolved cardiac imaging showed comparable quality across all fat-suppressed sequences, with no significant streaking artifacts observed. Free-running bSSFP with LIBOR required the lowest SAR, up to a sixfold decrease compared with FISS.</p><p><strong>Conclusion: </strong>The tested sequences performed similarly in SNR and CNR but LIBOR offered the lowest SAR, making it a promising candidate for applications where RF energy deposition is a concern.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison between fast-interrupted steady-state (FISS) and rapid water-excitation pulses for fat signal suppression in free-running whole-heart MRI at 1.5 T.\",\"authors\":\"Yasaman Safarkhanlo, Jérôme Yerly, Mariana B L Falcão, Adèle L C Mackowiak, Davide Piccini, Matthias Stuber, Bernd Jung, Christoph Gräni, Jessica A M Bastiaansen\",\"doi\":\"10.1007/s10334-025-01273-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Free-running whole-heart MRI using balanced steady-state free precession (bSSFP) sequences offer high SNR and myocardial tissue contrast. However, an inadequate fat signal suppression may introduce artifacts and is particularly challenging with non-Cartesian readouts. The aim of this study was to evaluate different fat-signal suppression methods for whole-heart free-running MRI at 1.5 T using numerical simulations, phantom, and cardiac MRI experiments without the use of contrast agents.</p><p><strong>Methods: </strong>Binomial off-resonant rectangular (BORR), lipid insensitive binomial off-resonant RF excitation (LIBRE), and lipid insensitive binomial off-resonant (LIBOR) pulses were implemented within a 3D radial bSSFP sequence. Their pulse parameters were optimized for fat signal suppression at 1.5 T using simulations and phantom experiments. Optimized protocols, along with a free-running fast interrupted steady-state (FISS) and non-fat suppressed bSSFP sequence, were used to acquire phantom and cardiac data in five volunteers. SAR values were recorded. The SNR and CNR<sub>Water-Fat</sub> were measured in phantom data, while SNR and CNR<sub>Blood-Myocardium</sub> were quantified in volunteers using reconstruction without motion correction. Motion-resolved reconstructions were used for qualitative assessments. Statistical differences were analyzed using one-way ANOVA.</p><p><strong>Results: </strong>LIBOR had the highest CNR<sub>Water-Fat</sub> (276.8 ± 2.5) in phantoms, followed by LIBRE (268.1 ± 2.6), BORR (249.9 ± 2.2), and FISS (212.7 ± 2.7), though these differences were not statistically significant (p > 0.05). In volunteers, BORR had the highest SNR in the ventricular blood pool (17.0 ± 1.5), and LIBRE had the highest CNR<sub>Blood-Fat</sub> (29.4 ± 9.3). FISS had the highest CNR<sub>Blood-Myocardium</sub> (29.0 ± 8.9), but the differences were not significant (p > 0.05). Motion-resolved cardiac imaging showed comparable quality across all fat-suppressed sequences, with no significant streaking artifacts observed. Free-running bSSFP with LIBOR required the lowest SAR, up to a sixfold decrease compared with FISS.</p><p><strong>Conclusion: </strong>The tested sequences performed similarly in SNR and CNR but LIBOR offered the lowest SAR, making it a promising candidate for applications where RF energy deposition is a concern.</p>\",\"PeriodicalId\":18067,\"journal\":{\"name\":\"Magnetic Resonance Materials in Physics, Biology and Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Magnetic Resonance Materials in Physics, Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10334-025-01273-z\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic Resonance Materials in Physics, Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10334-025-01273-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Comparison between fast-interrupted steady-state (FISS) and rapid water-excitation pulses for fat signal suppression in free-running whole-heart MRI at 1.5 T.
Background: Free-running whole-heart MRI using balanced steady-state free precession (bSSFP) sequences offer high SNR and myocardial tissue contrast. However, an inadequate fat signal suppression may introduce artifacts and is particularly challenging with non-Cartesian readouts. The aim of this study was to evaluate different fat-signal suppression methods for whole-heart free-running MRI at 1.5 T using numerical simulations, phantom, and cardiac MRI experiments without the use of contrast agents.
Methods: Binomial off-resonant rectangular (BORR), lipid insensitive binomial off-resonant RF excitation (LIBRE), and lipid insensitive binomial off-resonant (LIBOR) pulses were implemented within a 3D radial bSSFP sequence. Their pulse parameters were optimized for fat signal suppression at 1.5 T using simulations and phantom experiments. Optimized protocols, along with a free-running fast interrupted steady-state (FISS) and non-fat suppressed bSSFP sequence, were used to acquire phantom and cardiac data in five volunteers. SAR values were recorded. The SNR and CNRWater-Fat were measured in phantom data, while SNR and CNRBlood-Myocardium were quantified in volunteers using reconstruction without motion correction. Motion-resolved reconstructions were used for qualitative assessments. Statistical differences were analyzed using one-way ANOVA.
Results: LIBOR had the highest CNRWater-Fat (276.8 ± 2.5) in phantoms, followed by LIBRE (268.1 ± 2.6), BORR (249.9 ± 2.2), and FISS (212.7 ± 2.7), though these differences were not statistically significant (p > 0.05). In volunteers, BORR had the highest SNR in the ventricular blood pool (17.0 ± 1.5), and LIBRE had the highest CNRBlood-Fat (29.4 ± 9.3). FISS had the highest CNRBlood-Myocardium (29.0 ± 8.9), but the differences were not significant (p > 0.05). Motion-resolved cardiac imaging showed comparable quality across all fat-suppressed sequences, with no significant streaking artifacts observed. Free-running bSSFP with LIBOR required the lowest SAR, up to a sixfold decrease compared with FISS.
Conclusion: The tested sequences performed similarly in SNR and CNR but LIBOR offered the lowest SAR, making it a promising candidate for applications where RF energy deposition is a concern.
期刊介绍：
MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include:
advances in materials, hardware and software in magnetic resonance technology,
new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine,
study of animal models and intact cells using magnetic resonance,
reports of clinical trials on humans and clinical validation of magnetic resonance protocols.
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