Andrea Leung, Kathryn Haran, Georgia Marquez-Grap, Kristen Chang, Chandler E Johnson, Allison Kranyak, Tina Bhutani, Wilson Liao
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The demographics, disease severity, family history, sleep quality (PROMIS 8a, PROMIS 8b, and Insomnia Severity Index), and mental health (Patient Health Questionnaire-8 and Generalized Anxiety Disorder-7) of participants were assessed. Descriptive analysis and logistic regression models were employed to examine sleep and mental health, adjusting for potential confounders like demographics and comorbidities.</p><p><strong>Results: </strong>A comparison of patients with psoriasis and healthy controls revealed worsened sleep and mental health outcomes in patients with psoriasis. Among participants with psoriasis, greater sleep impairment (Patient-Reported Outcomes Measurement Information System (PROMIS) 8a), sleep disturbance (PROMIS 8b), and insomnia were significantly associated with anxiety (ORa 1.22; 95% confidence interval (CI) 1.16, 1.30; ORa 1.26; 95% CI 1.16, 1.80; ORa 5.13; 95% CI 2.91, 9.33; respectively) and depression (ORa 1.42; 95% CI 1.32, 1.56; ORa 1.16; 95% CI 1.08, 1.26; ORa 7.04; 95% CI 4.01, 12.77; respectively).</p><p><strong>Conclusion: </strong>These findings underscore the importance of recognizing how psoriasis can impact mental health and sleep. Building a collaborative relationship between patients with psoriasis and their providers is essential to improve overall sleep and life quality.</p>","PeriodicalId":11186,"journal":{"name":"Dermatology and Therapy","volume":" ","pages":"2247-2254"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256367/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Impact of Psoriasis on Sleep Quality: Examining the Relationship Between Psoriasis, Sleep, and Mental Health.\",\"authors\":\"Andrea Leung, Kathryn Haran, Georgia Marquez-Grap, Kristen Chang, Chandler E Johnson, Allison Kranyak, Tina Bhutani, Wilson Liao\",\"doi\":\"10.1007/s13555-025-01449-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Psoriasis is a chronic immune-mediated skin disease with known physical and mental health comorbidities, such as cardiovascular disease, depression, and anxiety. 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Descriptive analysis and logistic regression models were employed to examine sleep and mental health, adjusting for potential confounders like demographics and comorbidities.</p><p><strong>Results: </strong>A comparison of patients with psoriasis and healthy controls revealed worsened sleep and mental health outcomes in patients with psoriasis. Among participants with psoriasis, greater sleep impairment (Patient-Reported Outcomes Measurement Information System (PROMIS) 8a), sleep disturbance (PROMIS 8b), and insomnia were significantly associated with anxiety (ORa 1.22; 95% confidence interval (CI) 1.16, 1.30; ORa 1.26; 95% CI 1.16, 1.80; ORa 5.13; 95% CI 2.91, 9.33; respectively) and depression (ORa 1.42; 95% CI 1.32, 1.56; ORa 1.16; 95% CI 1.08, 1.26; ORa 7.04; 95% CI 4.01, 12.77; respectively).</p><p><strong>Conclusion: </strong>These findings underscore the importance of recognizing how psoriasis can impact mental health and sleep. 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引用次数: 0
摘要
简介：银屑病是一种慢性免疫介导的皮肤病，具有已知的身体和精神健康合并症，如心血管疾病、抑郁和焦虑。由于瘙痒和疼痛等因素，牛皮癣对生活质量和睡眠也有重大影响。本研究旨在评估睡眠质量、心理健康和牛皮癣之间的关系，并特别研究睡眠质量差对牛皮癣患者心理健康结果的影响。方法：在这项横断面研究中，我们将556名参与者分为两个队列：487名参与者入组牛皮癣组，69名参与者入组健康对照组。评估参与者的人口统计学、疾病严重程度、家族史、睡眠质量（PROMIS 8a、PROMIS 8b和失眠严重程度指数）和心理健康（患者健康问卷-8和广泛性焦虑障碍-7）。采用描述性分析和逻辑回归模型来检查睡眠和心理健康，调整潜在的混杂因素，如人口统计学和合并症。结果：牛皮癣患者与健康对照者的比较显示，牛皮癣患者的睡眠和心理健康状况恶化。在牛皮癣患者中，严重的睡眠障碍（患者报告的结果测量信息系统（PROMIS） 8a）、睡眠障碍（PROMIS 8b）和失眠与焦虑显著相关(ORa 1.22；95%置信区间（CI） 1.16, 1.30；奥拉1.26;95% ci 1.16, 1.80；奥拉5.13;95% ci 2.91, 9.33；分别为)和抑郁(ORa 1.42；95% ci 1.32, 1.56；奥拉1.16;95% ci 1.08, 1.26；奥拉7.04;95% ci 4.01, 12.77；分别)。结论：这些发现强调了认识牛皮癣如何影响心理健康和睡眠的重要性。在牛皮癣患者和医生之间建立合作关系对于改善整体睡眠和生活质量至关重要。
The Impact of Psoriasis on Sleep Quality: Examining the Relationship Between Psoriasis, Sleep, and Mental Health.
Introduction: Psoriasis is a chronic immune-mediated skin disease with known physical and mental health comorbidities, such as cardiovascular disease, depression, and anxiety. Psoriasis also has a significant impact on quality of life and sleep due to factors like itch and pain. This study aims to assess the relationship between sleep quality, mental health, and psoriasis, and specifically investigate the impact of poor sleep quality on mental health outcomes within participants with psoriasis.
Methods: In this cross-sectional study, we enrolled 556 participants into two cohorts: 487 participants were enrolled into the psoriasis cohort, and 69 were enrolled into the healthy control cohort. The demographics, disease severity, family history, sleep quality (PROMIS 8a, PROMIS 8b, and Insomnia Severity Index), and mental health (Patient Health Questionnaire-8 and Generalized Anxiety Disorder-7) of participants were assessed. Descriptive analysis and logistic regression models were employed to examine sleep and mental health, adjusting for potential confounders like demographics and comorbidities.
Results: A comparison of patients with psoriasis and healthy controls revealed worsened sleep and mental health outcomes in patients with psoriasis. Among participants with psoriasis, greater sleep impairment (Patient-Reported Outcomes Measurement Information System (PROMIS) 8a), sleep disturbance (PROMIS 8b), and insomnia were significantly associated with anxiety (ORa 1.22; 95% confidence interval (CI) 1.16, 1.30; ORa 1.26; 95% CI 1.16, 1.80; ORa 5.13; 95% CI 2.91, 9.33; respectively) and depression (ORa 1.42; 95% CI 1.32, 1.56; ORa 1.16; 95% CI 1.08, 1.26; ORa 7.04; 95% CI 4.01, 12.77; respectively).
Conclusion: These findings underscore the importance of recognizing how psoriasis can impact mental health and sleep. Building a collaborative relationship between patients with psoriasis and their providers is essential to improve overall sleep and life quality.
期刊介绍：
Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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