{"title":"Oxidant-antioxidant平衡。","authors":"J F Cordier","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We briefly consider some examples illustrating the pathophysiologic roles of oxidants in lung injury: pathologic changes induced by hyperoxia (exudative alveolar oedema and proliferation of fibroblasts), cell toxicity (especially endothelial cells) and inactivation of alpha-1-proteinase inhibitor (by oxidation of a methionyl residue at the active site of the inhibitor). These suggest the possibility of a beneficial role for antioxidants in many types of lung injury.</p>","PeriodicalId":75642,"journal":{"name":"Bulletin europeen de physiopathologie respiratoire","volume":"23 4","pages":"273-4"},"PeriodicalIF":0.0000,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oxidant-antioxidant balance.\",\"authors\":\"J F Cordier\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We briefly consider some examples illustrating the pathophysiologic roles of oxidants in lung injury: pathologic changes induced by hyperoxia (exudative alveolar oedema and proliferation of fibroblasts), cell toxicity (especially endothelial cells) and inactivation of alpha-1-proteinase inhibitor (by oxidation of a methionyl residue at the active site of the inhibitor). These suggest the possibility of a beneficial role for antioxidants in many types of lung injury.</p>\",\"PeriodicalId\":75642,\"journal\":{\"name\":\"Bulletin europeen de physiopathologie respiratoire\",\"volume\":\"23 4\",\"pages\":\"273-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin europeen de physiopathologie respiratoire\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin europeen de physiopathologie respiratoire","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
We briefly consider some examples illustrating the pathophysiologic roles of oxidants in lung injury: pathologic changes induced by hyperoxia (exudative alveolar oedema and proliferation of fibroblasts), cell toxicity (especially endothelial cells) and inactivation of alpha-1-proteinase inhibitor (by oxidation of a methionyl residue at the active site of the inhibitor). These suggest the possibility of a beneficial role for antioxidants in many types of lung injury.
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