[慢性肾盂肾炎患儿氨苄西林肾内分布特点]。

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-07-01

V P Iakovlev, L Z Skala, A G Nekhorosheva, L A Shabalova, I N Borisov

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摘要

本文研究了21例行泌尿外科手术无肾功能不全的慢性肾盂肾炎患儿氨苄西林的药代动力学及肾脏分布特征。在肾实质、肾盂壁、输尿管膨出、计量器和膀胱中提供对氨苄西林敏感和部分中敏感微生物有效的抗生素浓度是可能的。尿系统组织中的氨苄西林浓度与血液中的氨苄西林浓度的对应程度高于尿液中的氨苄西林浓度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[Characteristics of intrarenal ampicillin distribution in chronic pyelonephritis in children].

Pharmacokinetics and characteristic features of ampicillin kidney distribution were studied in 21 children with chronic pyelonephritis without signs of renal insufficiency who had undergone urological operations. It was found possible to provide the antibiotic concentrations efficient against ampicillin sensitive and partially middle sensitive microorganisms in the renal parenchyma, pelvis wall, ureterocele, megaureter and urinary bladder. Ampicillin concentrations in tissues of the urinary system were shown to correspond to a higher extent to the concentrations attained in blood than those in urine.

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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology

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