胰岛素Lispro高产生物合成工艺研究

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shuchen Pei, Shusheng Liu, Jihong Luo, Junlin Chen, Hua Luo, Wen Wu, Xinan Chen
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引用次数: 0

摘要

胰岛素利斯普罗是一种速效胰岛素类似物,因其起效快、灵活性高而被广泛用于糖尿病的治疗。本研究建立了三步色谱纯化工艺,L发酵液可获得475 mg/L胰岛素利斯普罗。通过发酵、包涵体回收、复性、酶解、色谱纯化等多步骤工艺,获得了高纯度胰岛素利斯普罗产品。最终产品的纯度为99.7%。高分子量蛋白≤0.1%,锌含量0.41%,宿主细胞蛋白污染2.31 ng/mg,残留DNA 1.57 ng/mg。分析结果,包括保留时间,分子量和肽图谱,与理论预期一致,并与对照相匹配。该纯化工艺为胰岛素lispro的大规模生产提供了一种高效高效的方法,支持了重组胰岛素类似物的进一步开发,并为药物配方提供了高质量的活性药物成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

High-Yield Biosynthesis Process for Producing Insulin Lispro

High-Yield Biosynthesis Process for Producing Insulin Lispro

Insulin lispro, a fast-acting insulin analogue, is widely used for the treatment of diabetes due to its rapid onset and high flexibility. This study established a three-step chromatography purification process, L fermentation broth can obtain 475 mg/L insulin lispro. Through a multi-step process involving fermentation, recovery of inclusion bodies, renaturation, enzymatic digestion, and chromatographic purification, a high-purity insulin lispro product was obtained. The final product achieved a purity of 99.7%. The high molecular weight protein was ≤ 0.1%, zinc content was 0.41%, host cell protein contamination was 2.31 ng/mg, and residual DNA was 1.57 ng/mg. Analytical results, including retention time, molecular weight, and peptide mapping, were consistent with theoretical expectations and matched the control. This purification process provides a streamlined and cost-effective method for large-scale production of insulin lispro, supporting further development of recombinant insulin analogs and offering high-quality active pharmaceutical ingredients for pharmaceutical formulations.

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来源期刊
The Protein Journal
The Protein Journal 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
57
审稿时长
12 months
期刊介绍: The Protein Journal (formerly the Journal of Protein Chemistry) publishes original research work on all aspects of proteins and peptides. These include studies concerned with covalent or three-dimensional structure determination (X-ray, NMR, cryoEM, EPR/ESR, optical methods, etc.), computational aspects of protein structure and function, protein folding and misfolding, assembly, genetics, evolution, proteomics, molecular biology, protein engineering, protein nanotechnology, protein purification and analysis and peptide synthesis, as well as the elucidation and interpretation of the molecular bases of biological activities of proteins and peptides. We accept original research papers, reviews, mini-reviews, hypotheses, opinion papers, and letters to the editor.
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