性别对多发性硬化治疗的影响。

IF 6.9 2区医学 Q1 CLINICAL NEUROLOGY

Neurotherapeutics Pub Date : 2025-07-01 DOI:10.1016/j.neurot.2025.e00620

Patricia K. Coyle

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引用次数: 0

摘要

多发性硬化症（MS）是一种女性常见病。典型的受影响个体是育龄的年轻妇女。这篇文章强调当前对这种疾病的思考，使用基于性别的方法。它首先回顾了男性和女性在神经系统和免疫系统上的差异，以及对性激素的一般性讨论。人口统计学和临床影响的性别对MS的预后和症状被覆盖。怀孕，最好的研究性别为基础的条件，审查和包括生育和辅助生殖技术的最新咨询信息。MS问题在较少的研究领域涉及青春期，月经周期和更年期也提出。考虑性别对MS治疗反应的影响。最后一节涉及男性多发性硬化症的考虑。这个最新的审查提供了一个全面和简洁的方法，性别考虑在MS。

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Impact of sex on multiple sclerosis therapy

Multiple sclerosis (MS) is a female predominant disease. The prototypic affected individual is a young woman of childbearing age. This article emphasizes the current thinking about this disease, using a sex-based approach. It begins with a review of male vs. female differences in the nervous system and immune system, as well as a general discussion of sex hormones. The demographic and clinical impact of sex on MS prognosis and symptoms is covered. Pregnancy, the best studied sex-based condition, is reviewed and includes updated counseling information on fertility and assisted reproductive technology. MS issues in less well studied areas involving puberty, the menstrual cycle and menopause are also presented. The impact of sex on the MS therapeutic response is considered. The final section covers MS considerations in males. This up to date review provides a comprehensive and succinct approach to sex considerations in MS.

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来源期刊

Neurotherapeutics 医学-神经科学

CiteScore

11.00

自引率

3.50%

发文量

154

审稿时长

6-12 weeks

期刊介绍： Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities. The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field. Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.