{"title":"乳腺微型浸润性癌。","authors":"Rachel Han , Edi Brogi","doi":"10.1016/j.humpath.2025.105856","DOIUrl":null,"url":null,"abstract":"<div><div>Microinvasive breast carcinoma<span><span> is a diagnostically subtle form of invasive breast carcinoma with poorly characterized biologic behavior and limited evidence to guide treatment. This review addresses: (i) diagnostic criteria for microinvasive breast carcinoma; (ii) epidemiology and clinical features; (iii) histopathologic findings, including practical diagnostic clues and use of </span>immunohistochemistry; (iv) biomarker assessment; and (v) current clinical management strategies and challenges.</span></div></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"162 ","pages":"Article 105856"},"PeriodicalIF":2.6000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microinvasive carcinoma of the breast\",\"authors\":\"Rachel Han , Edi Brogi\",\"doi\":\"10.1016/j.humpath.2025.105856\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Microinvasive breast carcinoma<span><span> is a diagnostically subtle form of invasive breast carcinoma with poorly characterized biologic behavior and limited evidence to guide treatment. This review addresses: (i) diagnostic criteria for microinvasive breast carcinoma; (ii) epidemiology and clinical features; (iii) histopathologic findings, including practical diagnostic clues and use of </span>immunohistochemistry; (iv) biomarker assessment; and (v) current clinical management strategies and challenges.</span></div></div>\",\"PeriodicalId\":13062,\"journal\":{\"name\":\"Human pathology\",\"volume\":\"162 \",\"pages\":\"Article 105856\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0046817725001431\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human pathology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0046817725001431","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
Microinvasive breast carcinoma is a diagnostically subtle form of invasive breast carcinoma with poorly characterized biologic behavior and limited evidence to guide treatment. This review addresses: (i) diagnostic criteria for microinvasive breast carcinoma; (ii) epidemiology and clinical features; (iii) histopathologic findings, including practical diagnostic clues and use of immunohistochemistry; (iv) biomarker assessment; and (v) current clinical management strategies and challenges.
期刊介绍:
Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.