Varun Malik MBBS, PhD, Adrian D. Elliott PhD, Gijo Thomas PhD, Bradley Pitman CCDS, PhD, John L. Fitzgerald MBBS, PhD, Glenn D. Young MBBS, Leonard F. Arnolda MBBS, PhD, Dennis H. Lau MBBS, PhD, Prashanthan Sanders MBBS, PhD
{"title":"肺静脉隔离不改变心房颤动的心血管传入自主神经反射","authors":"Varun Malik MBBS, PhD, Adrian D. Elliott PhD, Gijo Thomas PhD, Bradley Pitman CCDS, PhD, John L. Fitzgerald MBBS, PhD, Glenn D. Young MBBS, Leonard F. Arnolda MBBS, PhD, Dennis H. Lau MBBS, PhD, Prashanthan Sanders MBBS, PhD","doi":"10.1002/joa3.70119","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Pulmonary vein isolation (PVI) remains the cornerstone of atrial fibrillation (AF) ablation. We previously demonstrated abnormal cardiac volume-sensitive reflexes (whose receptors are co-located in veno-atrial tissue) in AF patients. Whether PVI disrupts afferent nerves is unknown.</p>\n </section>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Evaluate whether PVI disrupts afferent volume-sensitive reflexes.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We consecutively studied autonomic reflexes in AF patients undergoing PVI, repeating the study post-PVI, if AF-free >6 months. We excluded patients with AF recurrence/procedural complications, allowing repeat procedures. We measured beat-to-beat mean arterial pressure (MAP) and heart rate (HR) continuously during low-level Lower Body Negative Pressure (LBNP), at 0, −20 and −40 mmHg (predominantly testing volume baroreceptors); Valsalva reflex (predominantly arterial baroreceptors); and Isometric Handgrip reflex (IHR, both). LBNP produces reflex vasoconstriction, evaluated from forearm blood flow (FBF ∝ 1/vascular resistance).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>18 patients were studied pre-PVI; <i>n</i> = 9 completed both visits. Mean age was 64 ± 3 years (78% male); BMI 28 ± 1 kg/m<sup>2</sup>; LA size 37 ± 2 mL/m<sup>2</sup>; and left ventricular function 65 ± 3%. Despite alterations in heart rate variability (HRV), there was no difference in IHR, Valsalva, or LBNP responses pre- versus post-PVI. During LBNP, MAP decreased slightly both pre- (−1.6 ± 3%) and post-PVI (−2.8 ± 1.8%); <i>p</i> = .7. HR increased similarly (<i>p</i> = .7) pre- (10.6 ± 6.4%) and post-PVI (7.2 ± 1.5%). FBF response was unchanged (<i>p</i> = .8). Resting (arterial) baroreflex sensitivity was unaltered.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>PVI does not impair cardiovascular reflexes involving afferent baroreceptors, suggesting HRV changes reflect efferent modulation or ablation adequacy rather than afferent disruption. Whether disrupting sino-atrial efferent nerves represents a marker of adequate ablation or influences PVI outcomes requires evaluation.</p>\n </section>\n </div>","PeriodicalId":15174,"journal":{"name":"Journal of Arrhythmia","volume":"41 3","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.70119","citationCount":"0","resultStr":"{\"title\":\"Pulmonary vein isolation does not alter cardiovascular afferent autonomic reflexes in atrial fibrillation\",\"authors\":\"Varun Malik MBBS, PhD, Adrian D. Elliott PhD, Gijo Thomas PhD, Bradley Pitman CCDS, PhD, John L. Fitzgerald MBBS, PhD, Glenn D. Young MBBS, Leonard F. Arnolda MBBS, PhD, Dennis H. Lau MBBS, PhD, Prashanthan Sanders MBBS, PhD\",\"doi\":\"10.1002/joa3.70119\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Pulmonary vein isolation (PVI) remains the cornerstone of atrial fibrillation (AF) ablation. We previously demonstrated abnormal cardiac volume-sensitive reflexes (whose receptors are co-located in veno-atrial tissue) in AF patients. Whether PVI disrupts afferent nerves is unknown.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>Evaluate whether PVI disrupts afferent volume-sensitive reflexes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We consecutively studied autonomic reflexes in AF patients undergoing PVI, repeating the study post-PVI, if AF-free >6 months. We excluded patients with AF recurrence/procedural complications, allowing repeat procedures. We measured beat-to-beat mean arterial pressure (MAP) and heart rate (HR) continuously during low-level Lower Body Negative Pressure (LBNP), at 0, −20 and −40 mmHg (predominantly testing volume baroreceptors); Valsalva reflex (predominantly arterial baroreceptors); and Isometric Handgrip reflex (IHR, both). LBNP produces reflex vasoconstriction, evaluated from forearm blood flow (FBF ∝ 1/vascular resistance).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>18 patients were studied pre-PVI; <i>n</i> = 9 completed both visits. Mean age was 64 ± 3 years (78% male); BMI 28 ± 1 kg/m<sup>2</sup>; LA size 37 ± 2 mL/m<sup>2</sup>; and left ventricular function 65 ± 3%. Despite alterations in heart rate variability (HRV), there was no difference in IHR, Valsalva, or LBNP responses pre- versus post-PVI. During LBNP, MAP decreased slightly both pre- (−1.6 ± 3%) and post-PVI (−2.8 ± 1.8%); <i>p</i> = .7. HR increased similarly (<i>p</i> = .7) pre- (10.6 ± 6.4%) and post-PVI (7.2 ± 1.5%). FBF response was unchanged (<i>p</i> = .8). Resting (arterial) baroreflex sensitivity was unaltered.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>PVI does not impair cardiovascular reflexes involving afferent baroreceptors, suggesting HRV changes reflect efferent modulation or ablation adequacy rather than afferent disruption. Whether disrupting sino-atrial efferent nerves represents a marker of adequate ablation or influences PVI outcomes requires evaluation.</p>\\n </section>\\n </div>\",\"PeriodicalId\":15174,\"journal\":{\"name\":\"Journal of Arrhythmia\",\"volume\":\"41 3\",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.70119\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Arrhythmia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/joa3.70119\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Arrhythmia","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/joa3.70119","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Pulmonary vein isolation does not alter cardiovascular afferent autonomic reflexes in atrial fibrillation
Background
Pulmonary vein isolation (PVI) remains the cornerstone of atrial fibrillation (AF) ablation. We previously demonstrated abnormal cardiac volume-sensitive reflexes (whose receptors are co-located in veno-atrial tissue) in AF patients. Whether PVI disrupts afferent nerves is unknown.
We consecutively studied autonomic reflexes in AF patients undergoing PVI, repeating the study post-PVI, if AF-free >6 months. We excluded patients with AF recurrence/procedural complications, allowing repeat procedures. We measured beat-to-beat mean arterial pressure (MAP) and heart rate (HR) continuously during low-level Lower Body Negative Pressure (LBNP), at 0, −20 and −40 mmHg (predominantly testing volume baroreceptors); Valsalva reflex (predominantly arterial baroreceptors); and Isometric Handgrip reflex (IHR, both). LBNP produces reflex vasoconstriction, evaluated from forearm blood flow (FBF ∝ 1/vascular resistance).
Results
18 patients were studied pre-PVI; n = 9 completed both visits. Mean age was 64 ± 3 years (78% male); BMI 28 ± 1 kg/m2; LA size 37 ± 2 mL/m2; and left ventricular function 65 ± 3%. Despite alterations in heart rate variability (HRV), there was no difference in IHR, Valsalva, or LBNP responses pre- versus post-PVI. During LBNP, MAP decreased slightly both pre- (−1.6 ± 3%) and post-PVI (−2.8 ± 1.8%); p = .7. HR increased similarly (p = .7) pre- (10.6 ± 6.4%) and post-PVI (7.2 ± 1.5%). FBF response was unchanged (p = .8). Resting (arterial) baroreflex sensitivity was unaltered.
Conclusion
PVI does not impair cardiovascular reflexes involving afferent baroreceptors, suggesting HRV changes reflect efferent modulation or ablation adequacy rather than afferent disruption. Whether disrupting sino-atrial efferent nerves represents a marker of adequate ablation or influences PVI outcomes requires evaluation.
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