金/银协同催化三组分多米诺级联环化合成4h -咪唑-恶二嗪-4-酮

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-06-23 DOI:10.1039/d5qo00540j

Dongfang Jiang, Zhenjie Qi, Haifei Wang, Feng Liu, Can Yang, Xin Li, Hongchi Zhou

{"title":"金/银协同催化三组分多米诺级联环化合成4h -咪唑-恶二嗪-4-酮","authors":"Dongfang Jiang, Zhenjie Qi, Haifei Wang, Feng Liu, Can Yang, Xin Li, Hongchi Zhou","doi":"10.1039/d5qo00540j","DOIUrl":null,"url":null,"abstract":"A novel and efficient method for synthesizing a wide range of 4H-imidazo-oxadiazin-4-ones was achieved through a three-component domino cascade cyclization reaction of N-tosylhydrazones with α, β-unsaturated acids and amines, utilizing Au/Ag dual catalysis,TBN asoxidant and DBU as base. This protocol boasts mild reaction conditions, broad substrate compatibility, and good functional group tolerance.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"50 1","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Au/Ag Synergistic Catalyzed Synthesis of 4H-imidazo-oxadiazin-4-ones via Three-Component Domino Cascade Cyclization\",\"authors\":\"Dongfang Jiang, Zhenjie Qi, Haifei Wang, Feng Liu, Can Yang, Xin Li, Hongchi Zhou\",\"doi\":\"10.1039/d5qo00540j\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A novel and efficient method for synthesizing a wide range of 4H-imidazo-oxadiazin-4-ones was achieved through a three-component domino cascade cyclization reaction of N-tosylhydrazones with α, β-unsaturated acids and amines, utilizing Au/Ag dual catalysis,TBN asoxidant and DBU as base. This protocol boasts mild reaction conditions, broad substrate compatibility, and good functional group tolerance.\",\"PeriodicalId\":97,\"journal\":{\"name\":\"Organic Chemistry Frontiers\",\"volume\":\"50 1\",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Chemistry Frontiers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5qo00540j\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5qo00540j","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

以Au/Ag双催化，TBN为氧化剂，DBU为碱，通过n-甲酰基腙与α、β-不饱和酸和胺的三组分多米诺级联环化反应，获得了一种新的高效合成广泛的4h -咪唑-恶二嗪-4-酮的方法。该方案具有反应条件温和、底物相容性广、官能团耐受性好等优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Au/Ag Synergistic Catalyzed Synthesis of 4H-imidazo-oxadiazin-4-ones via Three-Component Domino Cascade Cyclization

A novel and efficient method for synthesizing a wide range of 4H-imidazo-oxadiazin-4-ones was achieved through a three-component domino cascade cyclization reaction of N-tosylhydrazones with α, β-unsaturated acids and amines, utilizing Au/Ag dual catalysis,TBN asoxidant and DBU as base. This protocol boasts mild reaction conditions, broad substrate compatibility, and good functional group tolerance.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.