{"title":"乳腺癌幸存者上肢功能的预测因素。","authors":"Alper Tuğral, Yeşim Bakar, Murat Akyol","doi":"10.1002/pri.70082","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>Deteriorated upper extremity function is a leading cause of potential disability and functional decline in breast cancer survivors (BCS) not only during their active treatment but also in their survivorship continuum. Fatigue and decreased muscle strength are the prominent ones that can account for decreased upper extremity function. Therefore, this study aimed to explore the potential contributors to the upper extremity function of BCS.</p><p><strong>Methods: </strong>A total of 100 BCS were included. Handgrip strength (HGS) was assessed with a dynamometer while fatigue and self-reported upper extremity function were assessed with the Fatigue Severity Scale (FSS), Disabilities of Arm, Shoulder, and Hand Questionnaire (DASH), respectively. To control the potential confounding effect of the handedness, the mean value of HGS was used in the regression model.</p><p><strong>Results: </strong>HGS was found to be significantly higher on the right side compared to the left side (22.71 ± 3.51 kg vs. 21.45 ± 3.66 kg, t = 5.328, p < 0.001). The mean scores of DASH and FSS were found 21.97 ± 15.62, and 39.62 ± 12.16, respectively. The multivariate linear regression analysis showed that a total of 26.9% of the cumulative variance in DASH is explained by the mean HGS, FSS, and body mass index (BMI) (F (4,95) = 11.793, p < 0.001, R<sup>2</sup> = 0.269, Cohen's f<sup>2</sup>:0.54). There were no significant effects and/or interactions of any clinical features of BCS on DASH. FSS and DASH also significantly correlated with each other (r = 0.49, p < 0.001).</p><p><strong>Discussion: </strong>This study showed that HGS shows itself as a significant outcome measure to predict upper extremity function in BCS. Because BCS can experience fatigue even years after the completion of primary treatment, it is noteworthy to consider it when evaluating the function of BCS.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04245657.</p>","PeriodicalId":47243,"journal":{"name":"Physiotherapy Research International","volume":"30 3","pages":"e70082"},"PeriodicalIF":1.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Predictors of Upper Extremity Function in Breast Cancer Survivors.\",\"authors\":\"Alper Tuğral, Yeşim Bakar, Murat Akyol\",\"doi\":\"10.1002/pri.70082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong>Deteriorated upper extremity function is a leading cause of potential disability and functional decline in breast cancer survivors (BCS) not only during their active treatment but also in their survivorship continuum. Fatigue and decreased muscle strength are the prominent ones that can account for decreased upper extremity function. Therefore, this study aimed to explore the potential contributors to the upper extremity function of BCS.</p><p><strong>Methods: </strong>A total of 100 BCS were included. Handgrip strength (HGS) was assessed with a dynamometer while fatigue and self-reported upper extremity function were assessed with the Fatigue Severity Scale (FSS), Disabilities of Arm, Shoulder, and Hand Questionnaire (DASH), respectively. To control the potential confounding effect of the handedness, the mean value of HGS was used in the regression model.</p><p><strong>Results: </strong>HGS was found to be significantly higher on the right side compared to the left side (22.71 ± 3.51 kg vs. 21.45 ± 3.66 kg, t = 5.328, p < 0.001). The mean scores of DASH and FSS were found 21.97 ± 15.62, and 39.62 ± 12.16, respectively. 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引用次数: 0
摘要
背景和目的：上肢功能恶化是乳腺癌幸存者（BCS）潜在残疾和功能下降的主要原因，不仅在其积极治疗期间，而且在其生存过程中也是如此。疲劳和肌力下降是上肢功能下降的主要原因。因此，本研究旨在探讨影响BCS上肢功能的潜在因素。方法：共纳入100例BCS。用测功仪评估握力（HGS），分别用疲劳严重程度量表（FSS）和手臂、肩、手残疾问卷（DASH）评估疲劳和自述上肢功能。为了控制利手性的潜在混淆效应，回归模型采用HGS的平均值。结果：右侧HGS明显高于左侧（22.71±3.51 kg比21.45±3.66 kg, t = 5.328, p = 0.269, Cohen’s f2:0.54）。BCS的任何临床特征对DASH没有显著影响和/或相互作用。讨论：本研究显示HGS是预测BCS患者上肢功能的重要指标。由于BCS在初次治疗完成数年后仍可能出现疲劳，因此在评估BCS功能时应考虑到这一点。试验注册：ClinicalTrials.gov标识符：NCT04245657。
Predictors of Upper Extremity Function in Breast Cancer Survivors.
Background and purpose: Deteriorated upper extremity function is a leading cause of potential disability and functional decline in breast cancer survivors (BCS) not only during their active treatment but also in their survivorship continuum. Fatigue and decreased muscle strength are the prominent ones that can account for decreased upper extremity function. Therefore, this study aimed to explore the potential contributors to the upper extremity function of BCS.
Methods: A total of 100 BCS were included. Handgrip strength (HGS) was assessed with a dynamometer while fatigue and self-reported upper extremity function were assessed with the Fatigue Severity Scale (FSS), Disabilities of Arm, Shoulder, and Hand Questionnaire (DASH), respectively. To control the potential confounding effect of the handedness, the mean value of HGS was used in the regression model.
Results: HGS was found to be significantly higher on the right side compared to the left side (22.71 ± 3.51 kg vs. 21.45 ± 3.66 kg, t = 5.328, p < 0.001). The mean scores of DASH and FSS were found 21.97 ± 15.62, and 39.62 ± 12.16, respectively. The multivariate linear regression analysis showed that a total of 26.9% of the cumulative variance in DASH is explained by the mean HGS, FSS, and body mass index (BMI) (F (4,95) = 11.793, p < 0.001, R2 = 0.269, Cohen's f2:0.54). There were no significant effects and/or interactions of any clinical features of BCS on DASH. FSS and DASH also significantly correlated with each other (r = 0.49, p < 0.001).
Discussion: This study showed that HGS shows itself as a significant outcome measure to predict upper extremity function in BCS. Because BCS can experience fatigue even years after the completion of primary treatment, it is noteworthy to consider it when evaluating the function of BCS.
期刊介绍：
Physiotherapy Research International is an international peer reviewed journal dedicated to the exchange of knowledge that is directly relevant to specialist areas of physiotherapy theory, practice, and research. Our aim is to promote a high level of scholarship and build on the current evidence base to inform the advancement of the physiotherapy profession. We publish original research on a wide range of topics e.g. Primary research testing new physiotherapy treatments; methodological research; measurement and outcome research and qualitative research of interest to researchers, clinicians and educators. Further, we aim to publish high quality papers that represent the range of cultures and settings where physiotherapy services are delivered. We attract a wide readership from physiotherapists and others working in diverse clinical and academic settings. We aim to promote an international debate amongst the profession about current best evidence based practice. Papers are directed primarily towards the physiotherapy profession, but can be relevant to a wide range of professional groups. The growth of interdisciplinary research is also key to our aims and scope, and we encourage relevant submissions from other professional groups. The journal actively encourages submissions which utilise a breadth of different methodologies and research designs to facilitate addressing key questions related to the physiotherapy practice. PRI seeks to encourage good quality topical debates on a range of relevant issues and promote critical reflection on decision making and implementation of physiotherapy interventions.
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