靶向质膜胆固醇作为一种新的抗癌疗法。

IF 19.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2025-06-19 DOI:10.1016/j.tips.2025.06.001

Alfredo Erazo-Oliveras, Mónica Muñoz-Vega, Robert S Chapkin

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引用次数: 0

摘要

在结直肠癌（CRC）的背景下，治疗致癌Wnt信号的有效治疗策略仍然难以捉摸。Cho及其同事的一项新研究描述了典型腺瘤性息肉病（APC）功能丧失、膜胆固醇和特异性抑制胆固醇- dvl -β-catenin信号轴的创新药物靶点之间的一种新的机制联系。

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Targeting plasma membrane cholesterol as a novel anticancer therapy.

An effective therapeutic strategy to treat oncogenic Wnt signaling in the context of colorectal cancer (CRC) remains elusive. A new study from Cho and colleagues describes a novel mechanistic link between the loss of canonical adenomatous polyposis coli (APC) function, membrane cholesterol, and an innovative drug target to specifically suppress the cholesterol-Dvl-β-catenin signaling axis.

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.