血栓性微血管病的分子基础。

IF 5.5 2区医学 Q1 HEMATOLOGY

Journal of Thrombosis and Haemostasis Pub Date : 2025-06-18 DOI:10.1016/j.jtha.2025.06.014

Yuan Zhou, Joel Moake, Jing-Fei Dong

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引用次数: 0

摘要

血栓性血小板减少性紫癜（TTP）和溶血性尿毒症综合征（HUS）是血栓性微血管病变（TMA）的两个指标条件。虽然归类为TMA的疾病具有共同的临床特征，但其潜在原因却有很大不同。TMA的诊断具有挑战性，但如果没有适当和及时的诊断和治疗，则会危及生命。在这篇综述中，我们讨论了近年来在TTP和溶血性尿毒综合征的分子基础、临床流行病学和治疗方面的研究进展。

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Molecular Basis of Thrombotic Microangiopathy.

Thrombotic thrombocytopenic purpura (TTP) and Hemolytic uremic syndrome (HUS) are two index conditions of thrombotic microangiopathy (TMA). While conditions classified as TMA share common clinical characteristics, their underlying causes differ significantly. TMA is challenging to diagnose but life threating without proper and timely diagnosis and treatments. In this review, we discuss recent advances in understanding of the molecular basis, clinical epidemiology, and treatments of TTP and HUS.

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来源期刊

Journal of Thrombosis and Haemostasis 医学-外周血管病

CiteScore

24.30

自引率

3.80%

发文量

321

审稿时长

1 months

期刊介绍： The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.