Lin Li, Jiehao Zhou, Kun Song, Hongbo Liu, Xiao Wang, Yuqian Zhu, Zhijun Wang
{"title":"限制性液体复苏在急诊创伤失血性休克中的应用及对血气指标的影响。","authors":"Lin Li, Jiehao Zhou, Kun Song, Hongbo Liu, Xiao Wang, Yuqian Zhu, Zhijun Wang","doi":"10.1016/j.avsg.2025.06.009","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to observe the application of restrictive fluid resuscitation in emergency traumatic hemorrhagic shock (THS) and impact on blood gas indicators.</p><p><strong>Methods: </strong>THS patients (n = 80) were divided into two groups: 40 cases in the active group received active fluid resuscitation, and 40 cases in the restricted group received restrictive fluid resuscitation. Blood gas indicators [blood lactate (BL), partial pressure of arterial blood carbon dioxide (PaCO<sub>2</sub>), and partial pressure of arterial blood oxygen (PaO<sub>2</sub>)], coagulation parameters [activated partial thromboplastin time (APTT), prothrombin time (PT), and thromboplastin time (TT)], inflammation indicators [interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α)] levels, complications, and resuscitation outcomes in the two groups were compared.</p><p><strong>Results: </strong>After 24 h of resuscitation in both groups, BL and PaCO<sub>2</sub> decreased and PaO<sub>2</sub> increased, and all of them were significantly improved in the restricted group compared with the active group. APTT, PT, and TT were prolonged, but were shorter in the restricted group than in the active group. Serum IL-6, IL-8, and TNF-α levels were reduced in both groups and were lower in the restricted group than in the active group. The overall incidence of complications within 1 week of resuscitation was [7.50% (3/40)] in the restricted group, which was lower than in the active group 25.00% (10/40). The success rate of resuscitation within 1 week after resuscitation was 95.00% (38/40) higher in the restricted group than 77.50% (31/40) in the active group (all P < 0.05).</p><p><strong>Conclusion: </strong>Compared with active fluid resuscitation, restrictive fluid resuscitation applied in the emergency treatment of THS patients has a better effect on the improvement of patients' blood gas indices, coagulation indices, and inflammation indices, and can effectively reduce the incidence of complications and enhance the success rate of resuscitation.</p>","PeriodicalId":8061,"journal":{"name":"Annals of vascular surgery","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of restrictive fluid resuscitation in emergency traumatic hemorrhagic shock and impact on blood gas indicators.\",\"authors\":\"Lin Li, Jiehao Zhou, Kun Song, Hongbo Liu, Xiao Wang, Yuqian Zhu, Zhijun Wang\",\"doi\":\"10.1016/j.avsg.2025.06.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The study aimed to observe the application of restrictive fluid resuscitation in emergency traumatic hemorrhagic shock (THS) and impact on blood gas indicators.</p><p><strong>Methods: </strong>THS patients (n = 80) were divided into two groups: 40 cases in the active group received active fluid resuscitation, and 40 cases in the restricted group received restrictive fluid resuscitation. Blood gas indicators [blood lactate (BL), partial pressure of arterial blood carbon dioxide (PaCO<sub>2</sub>), and partial pressure of arterial blood oxygen (PaO<sub>2</sub>)], coagulation parameters [activated partial thromboplastin time (APTT), prothrombin time (PT), and thromboplastin time (TT)], inflammation indicators [interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α)] levels, complications, and resuscitation outcomes in the two groups were compared.</p><p><strong>Results: </strong>After 24 h of resuscitation in both groups, BL and PaCO<sub>2</sub> decreased and PaO<sub>2</sub> increased, and all of them were significantly improved in the restricted group compared with the active group. APTT, PT, and TT were prolonged, but were shorter in the restricted group than in the active group. Serum IL-6, IL-8, and TNF-α levels were reduced in both groups and were lower in the restricted group than in the active group. The overall incidence of complications within 1 week of resuscitation was [7.50% (3/40)] in the restricted group, which was lower than in the active group 25.00% (10/40). The success rate of resuscitation within 1 week after resuscitation was 95.00% (38/40) higher in the restricted group than 77.50% (31/40) in the active group (all P < 0.05).</p><p><strong>Conclusion: </strong>Compared with active fluid resuscitation, restrictive fluid resuscitation applied in the emergency treatment of THS patients has a better effect on the improvement of patients' blood gas indices, coagulation indices, and inflammation indices, and can effectively reduce the incidence of complications and enhance the success rate of resuscitation.</p>\",\"PeriodicalId\":8061,\"journal\":{\"name\":\"Annals of vascular surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of vascular surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.avsg.2025.06.009\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of vascular surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.avsg.2025.06.009","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
Application of restrictive fluid resuscitation in emergency traumatic hemorrhagic shock and impact on blood gas indicators.
Objective: The study aimed to observe the application of restrictive fluid resuscitation in emergency traumatic hemorrhagic shock (THS) and impact on blood gas indicators.
Methods: THS patients (n = 80) were divided into two groups: 40 cases in the active group received active fluid resuscitation, and 40 cases in the restricted group received restrictive fluid resuscitation. Blood gas indicators [blood lactate (BL), partial pressure of arterial blood carbon dioxide (PaCO2), and partial pressure of arterial blood oxygen (PaO2)], coagulation parameters [activated partial thromboplastin time (APTT), prothrombin time (PT), and thromboplastin time (TT)], inflammation indicators [interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α)] levels, complications, and resuscitation outcomes in the two groups were compared.
Results: After 24 h of resuscitation in both groups, BL and PaCO2 decreased and PaO2 increased, and all of them were significantly improved in the restricted group compared with the active group. APTT, PT, and TT were prolonged, but were shorter in the restricted group than in the active group. Serum IL-6, IL-8, and TNF-α levels were reduced in both groups and were lower in the restricted group than in the active group. The overall incidence of complications within 1 week of resuscitation was [7.50% (3/40)] in the restricted group, which was lower than in the active group 25.00% (10/40). The success rate of resuscitation within 1 week after resuscitation was 95.00% (38/40) higher in the restricted group than 77.50% (31/40) in the active group (all P < 0.05).
Conclusion: Compared with active fluid resuscitation, restrictive fluid resuscitation applied in the emergency treatment of THS patients has a better effect on the improvement of patients' blood gas indices, coagulation indices, and inflammation indices, and can effectively reduce the incidence of complications and enhance the success rate of resuscitation.
期刊介绍：
Annals of Vascular Surgery, published eight times a year, invites original manuscripts reporting clinical and experimental work in vascular surgery for peer review. Articles may be submitted for the following sections of the journal:
Clinical Research (reports of clinical series, new drug or medical device trials)
Basic Science Research (new investigations, experimental work)
Case Reports (reports on a limited series of patients)
General Reviews (scholarly review of the existing literature on a relevant topic)
Developments in Endovascular and Endoscopic Surgery
Selected Techniques (technical maneuvers)
Historical Notes (interesting vignettes from the early days of vascular surgery)
Editorials/Correspondence
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