哺乳动物X染色体失活：一般原则和物种特异性考虑。

IF 6.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

EMBO Reports Pub Date : 2025-06-19 DOI:10.1038/s44319-025-00499-1

Charbel Alfeghaly, Claire Rougeulle

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引用次数: 0

摘要

X染色体失活（XCI）是一种哺乳动物剂量补偿机制，确保雄性和雌性之间X连锁基因的平衡表达。利用啮齿类动物模型进行的研究已经导致了关于XCI机制和动力学的重大发现，以及参与这一过程的分子参与者，包括长链非编码RNA Xist及其蛋白质伙伴。然而，XCI的一些特征在哺乳动物物种之间存在显著差异，不仅在有袋动物和胎盘哺乳动物之间，而且在后者内部也是如此。本文从进化的角度讨论了XCI的基本方面，强调了哺乳动物物种之间的保守特征和物种特异性变异。

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X chromosome inactivation in mammals: general principles and species-specific considerations.

X chromosome inactivation (XCI) is a mammalian dosage compensation mechanism that ensures balanced expression of X-linked genes between males and females. Research using rodent models has led to major discoveries regarding XCI mechanisms and dynamics, in addition to the molecular actors involved in this process, including the long noncoding RNA Xist and its protein partners. However, several features of XCI vary significantly across mammalian species, not only between marsupials and placental mammals, but also within the latter. This review discusses the fundamental aspects of XCI from an evolutionary perspective, highlighting both conserved features and species-specific variations across mammalian species.

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来源期刊

EMBO Reports 生物-生化与分子生物学

CiteScore

11.20

自引率

1.30%

发文量

267

审稿时长

1 months

期刊介绍： EMBO Reports is a scientific journal that specializes in publishing research articles in the fields of molecular biology, cell biology, and developmental biology. The journal is known for its commitment to publishing high-quality, impactful research that provides novel physiological and functional insights. These insights are expected to be supported by robust evidence, with independent lines of inquiry validating the findings. The journal's scope includes both long and short-format papers, catering to different types of research contributions. It values studies that: Communicate major findings: Articles that report significant discoveries or advancements in the understanding of biological processes at the molecular, cellular, and developmental levels. Confirm important findings: Research that validates or supports existing knowledge in the field, reinforcing the reliability of previous studies. Refute prominent claims: Studies that challenge or disprove widely accepted ideas or hypotheses in the biosciences, contributing to the correction and evolution of scientific understanding. Present null data: Papers that report negative results or findings that do not support a particular hypothesis, which are crucial for the scientific process as they help to refine or redirect research efforts. EMBO Reports is dedicated to maintaining high standards of scientific rigor and integrity, ensuring that the research it publishes contributes meaningfully to the advancement of knowledge in the life sciences. By covering a broad spectrum of topics and encouraging the publication of both positive and negative results, the journal plays a vital role in promoting a comprehensive and balanced view of scientific inquiry.