{"title":"胃癌部位特异性转移的临床病理特征和预后意义:基于人群的倾向评分匹配分析。","authors":"Xingbiao Huang, Zhe Li, Qiuyan Weng","doi":"10.1007/s12672-025-02865-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Distant metastasis complicates gastric cancer management and worsens patient outcomes. Understanding the clinicopathological characteristics and prognostic impact of site-specific metastases is crucial for improving treatment strategies and survival prediction.</p><p><strong>Methods: </strong>Data from 8338 metastatic gastric cancer patients (2010-2015) were retrieved from the SEER database. Patients were categorized by metastatic organ involvement. Chi-square tests analyzed clinicopathological differences. Cancer-specific survival (CSS) was assessed using Kaplan-Meier curves and the log-rank test. Independent prognostic factors were identified through Cox regression analysis. Propensity score matching minimized group heterogeneity.</p><p><strong>Results: </strong>The liver was the most common metastatic site (43.20%). Patients with bone, brain, or lung metastases had significantly shorter CSS compared to those without these metastases. CSS differences between liver metastasis and non-metastasis were not significant. Propensity score matching confirmed shorter CSS in patients with bone and lung metastases. Single-site metastasis had a better prognosis than multiple-site metastasis, with liver-only metastasis showing the best survival and bone-only metastasis the worst. Multivariate Cox regression identified bone, brain, and lung metastases, age, histology, tumor grade, T stage, N stage, primary tumor resection, and chemotherapy as independent prognostic factors.</p><p><strong>Conclusions: </strong>The metastatic site significantly influences the prognosis of gastric cancer. Single-site metastasis offers a survival advantage over multiple-site involvement, with liver metastasis showing a better prognosis and bone metastasis the worst. These findings emphasize the importance of site-specific management and the prognostic value of metastatic patterns in gastric cancer.</p>","PeriodicalId":11148,"journal":{"name":"Discover. Oncology","volume":"16 1","pages":"1164"},"PeriodicalIF":2.9000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181138/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinicopathological features and prognostic significance of site-specific metastasis in gastric cancer: a population-based, propensity score-matched analysis.\",\"authors\":\"Xingbiao Huang, Zhe Li, Qiuyan Weng\",\"doi\":\"10.1007/s12672-025-02865-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Distant metastasis complicates gastric cancer management and worsens patient outcomes. Understanding the clinicopathological characteristics and prognostic impact of site-specific metastases is crucial for improving treatment strategies and survival prediction.</p><p><strong>Methods: </strong>Data from 8338 metastatic gastric cancer patients (2010-2015) were retrieved from the SEER database. Patients were categorized by metastatic organ involvement. Chi-square tests analyzed clinicopathological differences. Cancer-specific survival (CSS) was assessed using Kaplan-Meier curves and the log-rank test. Independent prognostic factors were identified through Cox regression analysis. Propensity score matching minimized group heterogeneity.</p><p><strong>Results: </strong>The liver was the most common metastatic site (43.20%). Patients with bone, brain, or lung metastases had significantly shorter CSS compared to those without these metastases. CSS differences between liver metastasis and non-metastasis were not significant. Propensity score matching confirmed shorter CSS in patients with bone and lung metastases. Single-site metastasis had a better prognosis than multiple-site metastasis, with liver-only metastasis showing the best survival and bone-only metastasis the worst. Multivariate Cox regression identified bone, brain, and lung metastases, age, histology, tumor grade, T stage, N stage, primary tumor resection, and chemotherapy as independent prognostic factors.</p><p><strong>Conclusions: </strong>The metastatic site significantly influences the prognosis of gastric cancer. Single-site metastasis offers a survival advantage over multiple-site involvement, with liver metastasis showing a better prognosis and bone metastasis the worst. These findings emphasize the importance of site-specific management and the prognostic value of metastatic patterns in gastric cancer.</p>\",\"PeriodicalId\":11148,\"journal\":{\"name\":\"Discover. Oncology\",\"volume\":\"16 1\",\"pages\":\"1164\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181138/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Discover. Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12672-025-02865-w\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Discover. Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12672-025-02865-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Clinicopathological features and prognostic significance of site-specific metastasis in gastric cancer: a population-based, propensity score-matched analysis.
Objective: Distant metastasis complicates gastric cancer management and worsens patient outcomes. Understanding the clinicopathological characteristics and prognostic impact of site-specific metastases is crucial for improving treatment strategies and survival prediction.
Methods: Data from 8338 metastatic gastric cancer patients (2010-2015) were retrieved from the SEER database. Patients were categorized by metastatic organ involvement. Chi-square tests analyzed clinicopathological differences. Cancer-specific survival (CSS) was assessed using Kaplan-Meier curves and the log-rank test. Independent prognostic factors were identified through Cox regression analysis. Propensity score matching minimized group heterogeneity.
Results: The liver was the most common metastatic site (43.20%). Patients with bone, brain, or lung metastases had significantly shorter CSS compared to those without these metastases. CSS differences between liver metastasis and non-metastasis were not significant. Propensity score matching confirmed shorter CSS in patients with bone and lung metastases. Single-site metastasis had a better prognosis than multiple-site metastasis, with liver-only metastasis showing the best survival and bone-only metastasis the worst. Multivariate Cox regression identified bone, brain, and lung metastases, age, histology, tumor grade, T stage, N stage, primary tumor resection, and chemotherapy as independent prognostic factors.
Conclusions: The metastatic site significantly influences the prognosis of gastric cancer. Single-site metastasis offers a survival advantage over multiple-site involvement, with liver metastasis showing a better prognosis and bone metastasis the worst. These findings emphasize the importance of site-specific management and the prognostic value of metastatic patterns in gastric cancer.