根据日本社区连续尸检病例，半个世纪以来总前列腺癌和潜伏前列腺癌患病率的长期趋势：Hisayama研究

IF 3.2 3区医学 Q1 UROLOGY & NEPHROLOGY

European Urology Open Science Pub Date : 2025-06-19 DOI:10.1016/j.euros.2025.05.013

Junichi Taira , Kenji Kawatoko , Dai Takamatsu , Masaki Shiota , Hiroaki Ogata , Jun Hata , Emi Oishi , Satoko Sakata , Yoshihiko Furuta , Mao Shibata , Tomoyuki Ohara , Yoshinao Oda , Masatoshi Eto , Toshiharu Ninomiya

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引用次数: 0

摘要

背景和目的我们的目的是根据日本社区的连续尸检病例调查总前列腺癌（PC）和潜伏前列腺癌（LPC）的长期流行趋势。方法对1962年至2020年间日本某社区1355名40岁男性死者进行连续尸检。以15年为间隔计算总PC和LPC的时期患病率，并使用逻辑回归模型分析长期趋势。主要发现和局限性：总PC患病率(从1962-1976年的1.7%到2007-2020年的19%；p & lt;0.001)和LPC(从1962-1976年的1.3%上升到2007-2020年的11%；p & lt;0.001)随着时间的推移显著增加(ptrend <；0.001)。60-79岁年龄组的PC总患病率也有所上升(从1962-1976年的0.55%上升到2007-2020年的9.8%；P = 0.005)和≥80岁(从1962-1976年的6.5%到2007-2020年的26%；p = 0.003)。没有证据表明LPC的病理有长期变化。结论和临床意义在过去的60年中，尸检证实的总PC和LPC的流行率在日本社区有所增加。除了筛查和诊断技术的改进或人口老龄化之外，这种上升趋势可能还涉及其他因素。患者总结：我们使用来自日本人群尸检检查的数据来分析前列腺癌发生的长期趋势。我们发现，在过去的60年里，这个日本社区确诊前列腺癌和潜伏前列腺癌的发病率都有显著上升。

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Secular Trends in the Prevalence of Total and Latent Prostate Cancer over Half a Century According to Consecutive Autopsy Cases in a Japanese community: The Hisayama Study

Background and objective

Our aim was to investigate secular trends in the period prevalence of total prostate cancer (PC) and latent PC (LPC) according to consecutive autopsy cases in a Japanese community.

Methods

A total of 1355 deceased men aged >40 yr in a Japanese community underwent consecutive autopsy examination between 1962 and 2020. The period prevalence of total PC and of LPC was calculated for 15-yr intervals, and secular trends were analyzed using a logistic regression model.

Key findings and limitations

The period prevalence of both total PC (from 1.7% in 1962–1976 to 19% in 2007–2020; p < 0.001) and LPC (from 1.3% in 1962–1976 to 11% in 2007–2020; p < 0.001) significantly increased over time (p_trend < 0.001). The age-specific period prevalence of total PC also increased for the age groups 60–79 yr (from 0.55% in 1962–1976 to 9.8% in 2007–2020; p = 0.005) and ≥80 yr (from 6.5% in 1962–1976 to 26% in 2007–2020; p = 0.003). There was no evidence of a secular change in the pathology of LPC.

Conclusions and clinical implications

The period prevalence of autopsy-proven total PC and LPC increased over the past 60 yr in a Japanese community. It is likely that this upward trend has involved additional factors beyond improvements in screening and diagnostic techniques or the aging of the population.

Patient summary

We used data from autopsy examinations in a Japanese population to analyze long-term trends for the occurrence of prostate cancer. We found a significant rise in the occurrence of both diagnosed prostate cancer and latent prostate cancer over the past 60 years in this Japanese community.

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