身体组成和内脏脂肪在骨质疏松症亚型分化中的作用：来自生物电阻抗分析的见解

IF 1.5 Q3 ORTHOPEDICS

Journal of orthopaedics Pub Date : 2025-06-18 DOI:10.1016/j.jor.2025.06.014

N. Wergen , U. Maus , K. Schultz , H. Frohnhofen , D. Latz , C. Somsen , L. Mueller , C. Beyersdorf

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引用次数: 0

摘要

最近的研究表明，身体成分与骨质疏松症的发生和进展密切相关。特别是内脏脂肪，似乎通过其促炎特性影响骨质流失。然而，目前尚不清楚这种机制是否同样适用于不同形式的骨质疏松症。目的探讨绝经后骨质疏松症与老年性骨质疏松症的体成分（尤其是内脏脂肪）差异。参与者和环境共有47名患者被纳入前瞻性研究。老年骨质疏松组包括年龄≥80岁的患者（n = 20，平均年龄87.4），绝经后骨质疏松组包括年龄≤75岁的患者（n = 14，平均年龄68.8），对照组包括年龄≤75岁的患者（n = 13，平均年龄68.8），无骨质疏松性骨折或其他骨质疏松特异性危险因素。方法采用生物电阻抗分析（BIA）评估受试者的身体成分。其他评估包括基础骨学实验室测试、老年评估、肌肉减少症筛查（SARC-F）和使用临床虚弱量表（CFS）进行虚弱筛查。结果与对照组相比，老年骨质疏松组的肌肉质量、全身水分、无脂质量和BMI均显著降低。在绝经后组中也观察到类似的趋势，但没有统计学意义。值得注意的是，老年性骨质疏松症组内脏脂肪相对于总脂肪量的比例明显高于对照组和绝经后组。结论老年及绝经后骨质疏松症患者与非骨质疏松症患者体成分存在明显差异。特别是，内脏脂肪与老年性骨质疏松症之间的密切联系突出了BIA在早期风险检测和量身定制治疗策略开发中的潜在作用。

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The role of body composition and visceral fat in osteoporosis subtype differentiation: Insights from bioelectrical impedance analysis

Background

Recent studies have demonstrated a close link between body composition and the development and progression of osteoporosis. Visceral fat, in particular, appears to influence bone loss through its pro-inflammatory properties. However, it remains unclear whether this mechanism is equally relevant across different forms of osteoporosis.

Objective

To investigate whether body composition—especially visceral fat— differs between postmenopausal and senile osteoporosis.

Participants and setting

A total of 47 patients were prospectively enrolled. The senile osteoporosis group included patients aged ≥80 years (n = 20, mean age 87.4), the postmenopausal osteoporosis group included patients aged ≤75 years (n = 14, mean age 68.8), and the control group consisted of patients aged ≤75 years (n = 13, mean age 68.8) without osteoporotic fractures or other osteoporosis-specific risk factors.

Methods

Participants underwent bioelectrical impedance analysis (BIA) to assess body composition. Additional assessments included basic osteological laboratory testing, geriatric evaluation, sarcopenia screening (SARC-F), and frailty screening using the Clinical Frailty Scale (CFS).

Results

Muscle mass, total body water, fat-free mass, and BMI were significantly reduced in the senile osteoporosis group compared to controls. Similar trends were observed in the postmenopausal group, though without statistical significance. Notably, the senile osteoporosis group had a significantly higher proportion of visceral fat relative to total fat mass than both the control and postmenopausal groups.

Conclusion

Patients with senile and postmenopausal osteoporosis exhibit distinct differences in body composition compared to individuals without osteoporosis. In particular, the strong association between visceral fat and senile osteoporosis highlights a potential role for BIA in early risk detection and the development of tailored therapeutic strategies.

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.