Carlos E. Diaz-Castrillon MD , Derek Serna-Gallegos MD , Shwetabh Tarun BA , Pyongsoo Yoon MD , Johannes Bonatti MD , Danny Chu MD , David Kaczorowski MD , Francis D. Ferdinand MD , Jianhui Zhu PhD , Julie Phillippi PhD , Floyd Thoma BS , Danial Ahmad MD , Ibrahim Sultan MD
{"title":"急性A型主动脉夹层修复后气管切开术的意义:纵向结果和患者需要的相关因素","authors":"Carlos E. Diaz-Castrillon MD , Derek Serna-Gallegos MD , Shwetabh Tarun BA , Pyongsoo Yoon MD , Johannes Bonatti MD , Danny Chu MD , David Kaczorowski MD , Francis D. Ferdinand MD , Jianhui Zhu PhD , Julie Phillippi PhD , Floyd Thoma BS , Danial Ahmad MD , Ibrahim Sultan MD","doi":"10.1016/j.xjon.2025.02.018","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the factors associated with the need for tracheostomy after surgical repair of acute type A aortic dissection (ATAAD) and its implications for longitudinal outcomes.</div></div><div><h3>Methods</h3><div>This retrospective analysis of patients who underwent ATAAD repair from 2010 to 2020 focused on a comparison of patients who required a tracheostomy versus those who did not. Adjusted regression analysis and a classification and regression tree (CART) model were used to assess factors influencing the need for tracheostomy and its association with longitudinal survival.</div></div><div><h3>Results</h3><div>Fifty-two of the 552 patients in the study cohort (9.4%) required a tracheostomy, performed at a median of 12 days after ATAAD repair (interquartile range [IQR], 8-17 days). The CART analysis identified the number of reintubations and the duration of initial mechanical ventilation as key predictors of tracheostomy, with subgroups showing tracheostomy rates ranging from 7% to 100%. Nearly one-half of the patients had their tracheostomy removed successfully, with a median time to removal of 33 days (IQR, 17-67 days). Compared to nontracheostomized patients, tracheostomized patients had a higher 1-year readmission rate (44.23% vs 29.58%; <em>P</em> = .03), including in the intensive care unit setting (34.62% vs 16.10%; <em>P</em> < .001). They also had significantly lower survival rates at 1 year (77.8% vs 95.3%; <em>P</em> < .001), 5 years (62.1% vs 86.1%; <em>P</em> < .001), and 10 years (43.2% vs 73.5%; <em>P</em> < .001).</div></div><div><h3>Conclusions</h3><div>Tracheostomy is associated with significant longitudinal mortality and readmissions after ATAAD repair. The CART model highlights the relevance of reintubation for clinical decision making. Improved predictive models may enable early interventions, which could mitigate the effects of prolonged mechanical ventilation and improve resource utilization. Future research should focus on refining these models and assessing postoperative rehabilitation programs.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"25 ","pages":"Pages 1-9"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Implications of tracheostomy after acute type A aortic dissection repair: Longitudinal outcomes and factors associated with patients requiring it\",\"authors\":\"Carlos E. Diaz-Castrillon MD , Derek Serna-Gallegos MD , Shwetabh Tarun BA , Pyongsoo Yoon MD , Johannes Bonatti MD , Danny Chu MD , David Kaczorowski MD , Francis D. Ferdinand MD , Jianhui Zhu PhD , Julie Phillippi PhD , Floyd Thoma BS , Danial Ahmad MD , Ibrahim Sultan MD\",\"doi\":\"10.1016/j.xjon.2025.02.018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To analyze the factors associated with the need for tracheostomy after surgical repair of acute type A aortic dissection (ATAAD) and its implications for longitudinal outcomes.</div></div><div><h3>Methods</h3><div>This retrospective analysis of patients who underwent ATAAD repair from 2010 to 2020 focused on a comparison of patients who required a tracheostomy versus those who did not. Adjusted regression analysis and a classification and regression tree (CART) model were used to assess factors influencing the need for tracheostomy and its association with longitudinal survival.</div></div><div><h3>Results</h3><div>Fifty-two of the 552 patients in the study cohort (9.4%) required a tracheostomy, performed at a median of 12 days after ATAAD repair (interquartile range [IQR], 8-17 days). The CART analysis identified the number of reintubations and the duration of initial mechanical ventilation as key predictors of tracheostomy, with subgroups showing tracheostomy rates ranging from 7% to 100%. Nearly one-half of the patients had their tracheostomy removed successfully, with a median time to removal of 33 days (IQR, 17-67 days). Compared to nontracheostomized patients, tracheostomized patients had a higher 1-year readmission rate (44.23% vs 29.58%; <em>P</em> = .03), including in the intensive care unit setting (34.62% vs 16.10%; <em>P</em> < .001). They also had significantly lower survival rates at 1 year (77.8% vs 95.3%; <em>P</em> < .001), 5 years (62.1% vs 86.1%; <em>P</em> < .001), and 10 years (43.2% vs 73.5%; <em>P</em> < .001).</div></div><div><h3>Conclusions</h3><div>Tracheostomy is associated with significant longitudinal mortality and readmissions after ATAAD repair. The CART model highlights the relevance of reintubation for clinical decision making. Improved predictive models may enable early interventions, which could mitigate the effects of prolonged mechanical ventilation and improve resource utilization. Future research should focus on refining these models and assessing postoperative rehabilitation programs.</div></div>\",\"PeriodicalId\":74032,\"journal\":{\"name\":\"JTCVS open\",\"volume\":\"25 \",\"pages\":\"Pages 1-9\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JTCVS open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666273625000683\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JTCVS open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666273625000683","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的分析急性A型主动脉夹层(ATAAD)手术修复术后气管切开术的相关因素及其对纵向预后的影响。方法回顾性分析2010年至2020年接受ATAAD修复的患者,重点比较需要气管切开术和不需要气管切开术的患者。采用校正回归分析和分类回归树(CART)模型评估影响气管切开术需求的因素及其与纵向生存的关系。结果552例患者中有52例(9.4%)需要气管切开术,手术时间中位数为ATAAD修复后12天(四分位数间距[IQR], 8-17天)。CART分析确定了气管插管次数和首次机械通气持续时间是气管切开术的关键预测因素,亚组显示气管切开术率从7%到100%不等。近一半的患者成功切除了气管切开术,平均切除时间为33天(IQR, 17-67天)。与未行气管造口术的患者相比,气管造口术患者1年再入院率更高(44.23% vs 29.58%;P = .03),包括重症监护病房(34.62% vs 16.10%;P & lt;措施)。他们的1年生存率也明显较低(77.8% vs 95.3%;P & lt;.001), 5年(62.1% vs 86.1%;P & lt;.001), 10年(43.2% vs 73.5%;P & lt;措施)。结论吻合术与ATAAD修复后的纵向死亡率和再入院率显著相关。CART模型强调了再插管与临床决策的相关性。改进的预测模型可以实现早期干预,从而减轻长时间机械通气的影响,提高资源利用率。未来的研究应该集中在完善这些模型和评估术后康复计划。
Implications of tracheostomy after acute type A aortic dissection repair: Longitudinal outcomes and factors associated with patients requiring it
Objective
To analyze the factors associated with the need for tracheostomy after surgical repair of acute type A aortic dissection (ATAAD) and its implications for longitudinal outcomes.
Methods
This retrospective analysis of patients who underwent ATAAD repair from 2010 to 2020 focused on a comparison of patients who required a tracheostomy versus those who did not. Adjusted regression analysis and a classification and regression tree (CART) model were used to assess factors influencing the need for tracheostomy and its association with longitudinal survival.
Results
Fifty-two of the 552 patients in the study cohort (9.4%) required a tracheostomy, performed at a median of 12 days after ATAAD repair (interquartile range [IQR], 8-17 days). The CART analysis identified the number of reintubations and the duration of initial mechanical ventilation as key predictors of tracheostomy, with subgroups showing tracheostomy rates ranging from 7% to 100%. Nearly one-half of the patients had their tracheostomy removed successfully, with a median time to removal of 33 days (IQR, 17-67 days). Compared to nontracheostomized patients, tracheostomized patients had a higher 1-year readmission rate (44.23% vs 29.58%; P = .03), including in the intensive care unit setting (34.62% vs 16.10%; P < .001). They also had significantly lower survival rates at 1 year (77.8% vs 95.3%; P < .001), 5 years (62.1% vs 86.1%; P < .001), and 10 years (43.2% vs 73.5%; P < .001).
Conclusions
Tracheostomy is associated with significant longitudinal mortality and readmissions after ATAAD repair. The CART model highlights the relevance of reintubation for clinical decision making. Improved predictive models may enable early interventions, which could mitigate the effects of prolonged mechanical ventilation and improve resource utilization. Future research should focus on refining these models and assessing postoperative rehabilitation programs.