二茂镍催化β-酮酯的直接收敛α-酰胺化

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-05 DOI:10.1021/acs.orglett.5c0162110.1021/acs.orglett.5c01621

Kimberly R. Sharp, Sara Y. Siddiqui, Emily G. Nikas and Brian M. Stoltz*,

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引用次数: 0

摘要

无起始物质预官能化的含羰基化合物的α-酰胺化是科学界的一个持续挑战。在这里，二茂镍催化作用于β-酮酯的酰胺化。在两个耦合伙伴上实现了广泛的衬底公差，使应用朝着收敛合成策略发展。最初的机制研究表明复杂的激活途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Direct, Convergent α-Amidation of β-Keto Esters via Nickelocene Catalysis

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Direct, Convergent α-Amidation of β-Keto Esters via Nickelocene Catalysis

α-Amidation of carbonyl-containing compounds without prefunctionalization of starting materials represents a continuing challenge within the scientific community. Here, nickelocene is used catalytically to effect an amidation of β-keto esters. Broad substrate tolerance on both coupling partners is achieved, enabling the application toward a convergent synthetic strategy. Initial mechanistic investigations suggest complex activation pathways.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.