简化和加速汉堡-埃彭多夫大学医学中心的分子肿瘤委员会进程。

IF 4.4 3区医学 Q2 ONCOLOGY

Targeted Oncology Pub Date : 2025-06-17 DOI:10.1007/s11523-025-01160-6

Layla Tabea Riemann, Maximilian Ataian, Felicia P S Hähner, Benjamin Roth, Alexander Knurr, Anne Kamitz, Maximilian Christopeit, Carsten Bokemeyer, Frank Ückert

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引用次数: 0

摘要

背景：我们开发、引入并评估了分子肿瘤学优化临床评估（MONOCLE），这是一个安全的、开源的网络应用程序，位于汉堡-埃彭多夫大学医学中心（UKE），用于优化分子肿瘤板（MTB）中复杂癌症病例的分析和讨论。目的：MONOCLE规范和协调文件，同时其集成的知识连接器加速了个性化治疗的文献研究。患者和方法：该系统的设计融合了德国个性化医疗网络（DNPM）、参与MTB过程的医务人员和开发MONOCLE的团队的要求。可用性评估使用系统可用性量表（SUS）和用户任务。总体流程优化是通过可以执行的自动化任务的数量来衡量的。结果：MONOCLE于2024年6月投入临床实践，大大减少了记录时间，因为三个手动步骤现在自动运行，并且可以将数据传输到DNPM。它的可用性和SUS显示出积极的结果，范围在92.5到97.5之间。结论：作为标准化MTB文档的第一个开源和可扩展解决方案，MONOCLE可以被其他医疗中心广泛采用。

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Streamlining and Accelerating the Molecular Tumor Board Process at the University Medical Center Hamburg-Eppendorf.

Background: We developed, introduced, and evaluated Molecular ONcology Optimized CLinical Evaluation (MONOCLE), a secure, open-source web application at the University Medical Center Hamburg-Eppendorf (UKE), to optimize the analysis and discussion of complex cancer cases in molecular tumor boards (MTB).

Objective: MONOCLE standardizes and harmonizes documentation, while its integrated Knowledge Connector accelerates literature research for personalized treatment.

Patients and methods: The system was designed by merging the requirements of the German Network for Personalized Medicine (DNPM), the medical staff involved in the MTB process, and the team developing MONOCLE. The usability was evaluated using the System Usability Scale (SUS) and user tasks. Overall process optimization was measured by the number of automated tasks that can be performed.

Results: MONOCLE, introduced into clinical practice in June 2024, significantly reduces time for documentation, as three manual steps now run automatically, and transfer of the data to the DNPM is possible. Its usability and SUS showed positive results, ranging between 92.5 and 97.5.

Conclusions: As the first open-source and extendable solution for standardized MTB documentation, MONOCLE enables wider adoption by other medical centers.

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来源期刊

Targeted Oncology 医学-肿瘤学

CiteScore

8.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： Targeted Oncology addresses physicians and scientists committed to oncology and cancer research by providing a programme of articles on molecularly targeted pharmacotherapy in oncology. The journal includes: Original Research Articles on all aspects of molecularly targeted agents for the treatment of cancer, including immune checkpoint inhibitors and related approaches. Comprehensive narrative Review Articles and shorter Leading Articles discussing relevant clinically established as well as emerging agents and pathways. Current Opinion articles that place interesting areas in perspective. Therapy in Practice articles that provide a guide to the optimum management of a condition and highlight practical, clinically relevant considerations and recommendations. Systematic Reviews that use explicit, systematic methods as outlined by the PRISMA statement. Adis Drug Reviews of the properties and place in therapy of both newer and established targeted drugs in oncology.