婚姻状况是男性乳腺癌的独立预后因素:一项基于seer的队列研究

IF 2.9
Breast cancer (Tokyo, Japan) Pub Date : 2025-09-01 Epub Date: 2025-06-16 DOI:10.1007/s12282-025-01733-3
Ahmet Necati Sanli, Bilal Turan, Deniz Esin Tekcan Sanli, Fatih Aydogan, M Kadri Altundag
{"title":"婚姻状况是男性乳腺癌的独立预后因素:一项基于seer的队列研究","authors":"Ahmet Necati Sanli, Bilal Turan, Deniz Esin Tekcan Sanli, Fatih Aydogan, M Kadri Altundag","doi":"10.1007/s12282-025-01733-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Male breast cancer (MBC) is a rare malignancy, and research on its prognostic factors remains limited. Marital status has been identified as a prognostic determinant in various cancers; however, the impact of marital status on MBC survival outcomes remains understudied. This study examines the relationship between marital status and survival in MBC patients using a large, population-based cohort.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) 17 Registries database (2010-2021). MBC patients (n = 5,994) were categorized into four marital status groups: married, unmarried, divorced, and widowed. Kaplan-Meier survival curves, log-rank tests, and Cox proportional hazards models were used to assess overall survival (OS) and disease-specific survival (DSS).</p><p><strong>Results: </strong>Significant differences in OS and DSS were observed among marital status groups (p < 0.001). Widowed patients had the poorest survival outcomes, with a 2.59 times higher increased mortality risk (HR = 2.594, 95% CI: 2.246-2.996, p < 0.001) compared to married individuals in univariate analysis. This association remained significant in multivariate analysis, with widowed patients demonstrating a 1.72 times higher mortality risk (HR = 1.724, 95% CI: 1.421-2.092, p < 0.001) after adjustment for clinicopathological and demographic variables. Unmarried and divorced patients also had poorer survival outcomes than married patients, albeit with lower hazard ratios.</p><p><strong>Conclusions: </strong>Marital status is an independent prognostic factor in MBC, with widowed patients experiencing the poorest outcomes. These findings underscore the important role of social and psychological support in cancer prognosis. Integrating psychosocial support programs and patient-centered care approaches into oncological practice can help reduce survival disparities.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"1061-1074"},"PeriodicalIF":2.9000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394377/pdf/","citationCount":"0","resultStr":"{\"title\":\"Marital status as an independent prognostic factor in male breast cancer: a SEER-based cohort study.\",\"authors\":\"Ahmet Necati Sanli, Bilal Turan, Deniz Esin Tekcan Sanli, Fatih Aydogan, M Kadri Altundag\",\"doi\":\"10.1007/s12282-025-01733-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Male breast cancer (MBC) is a rare malignancy, and research on its prognostic factors remains limited. Marital status has been identified as a prognostic determinant in various cancers; however, the impact of marital status on MBC survival outcomes remains understudied. This study examines the relationship between marital status and survival in MBC patients using a large, population-based cohort.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) 17 Registries database (2010-2021). MBC patients (n = 5,994) were categorized into four marital status groups: married, unmarried, divorced, and widowed. Kaplan-Meier survival curves, log-rank tests, and Cox proportional hazards models were used to assess overall survival (OS) and disease-specific survival (DSS).</p><p><strong>Results: </strong>Significant differences in OS and DSS were observed among marital status groups (p < 0.001). Widowed patients had the poorest survival outcomes, with a 2.59 times higher increased mortality risk (HR = 2.594, 95% CI: 2.246-2.996, p < 0.001) compared to married individuals in univariate analysis. This association remained significant in multivariate analysis, with widowed patients demonstrating a 1.72 times higher mortality risk (HR = 1.724, 95% CI: 1.421-2.092, p < 0.001) after adjustment for clinicopathological and demographic variables. Unmarried and divorced patients also had poorer survival outcomes than married patients, albeit with lower hazard ratios.</p><p><strong>Conclusions: </strong>Marital status is an independent prognostic factor in MBC, with widowed patients experiencing the poorest outcomes. These findings underscore the important role of social and psychological support in cancer prognosis. Integrating psychosocial support programs and patient-centered care approaches into oncological practice can help reduce survival disparities.</p>\",\"PeriodicalId\":520574,\"journal\":{\"name\":\"Breast cancer (Tokyo, Japan)\",\"volume\":\" \",\"pages\":\"1061-1074\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394377/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Breast cancer (Tokyo, Japan)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12282-025-01733-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Breast cancer (Tokyo, Japan)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12282-025-01733-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/16 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:男性乳腺癌(MBC)是一种罕见的恶性肿瘤,对其预后因素的研究仍然有限。婚姻状况已被确定为各种癌症的预后决定因素;然而,婚姻状况对MBC生存结果的影响仍未得到充分研究。本研究通过大规模人群队列研究了婚姻状况与MBC患者生存之间的关系。方法:使用监测、流行病学和最终结果(SEER) 17个注册数据库(2010-2021)进行回顾性队列研究。将5994例MBC患者分为已婚、未婚、离婚、丧偶4组。Kaplan-Meier生存曲线、log-rank检验和Cox比例风险模型用于评估总生存期(OS)和疾病特异性生存期(DSS)。结论:婚姻状况是影响MBC预后的独立因素,丧偶患者预后最差。这些发现强调了社会和心理支持在癌症预后中的重要作用。将社会心理支持项目和以患者为中心的护理方法整合到肿瘤实践中可以帮助减少生存差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Marital status as an independent prognostic factor in male breast cancer: a SEER-based cohort study.

Marital status as an independent prognostic factor in male breast cancer: a SEER-based cohort study.

Marital status as an independent prognostic factor in male breast cancer: a SEER-based cohort study.

Background: Male breast cancer (MBC) is a rare malignancy, and research on its prognostic factors remains limited. Marital status has been identified as a prognostic determinant in various cancers; however, the impact of marital status on MBC survival outcomes remains understudied. This study examines the relationship between marital status and survival in MBC patients using a large, population-based cohort.

Methods: A retrospective cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) 17 Registries database (2010-2021). MBC patients (n = 5,994) were categorized into four marital status groups: married, unmarried, divorced, and widowed. Kaplan-Meier survival curves, log-rank tests, and Cox proportional hazards models were used to assess overall survival (OS) and disease-specific survival (DSS).

Results: Significant differences in OS and DSS were observed among marital status groups (p < 0.001). Widowed patients had the poorest survival outcomes, with a 2.59 times higher increased mortality risk (HR = 2.594, 95% CI: 2.246-2.996, p < 0.001) compared to married individuals in univariate analysis. This association remained significant in multivariate analysis, with widowed patients demonstrating a 1.72 times higher mortality risk (HR = 1.724, 95% CI: 1.421-2.092, p < 0.001) after adjustment for clinicopathological and demographic variables. Unmarried and divorced patients also had poorer survival outcomes than married patients, albeit with lower hazard ratios.

Conclusions: Marital status is an independent prognostic factor in MBC, with widowed patients experiencing the poorest outcomes. These findings underscore the important role of social and psychological support in cancer prognosis. Integrating psychosocial support programs and patient-centered care approaches into oncological practice can help reduce survival disparities.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信