儿科ITP的早期反应和长期预后:未来管理策略的探讨。

IF 3.8 2区 医学 Q1 HEMATOLOGY
Minghao Zhang, Xiaoming Wang, Ting Pu, Xiaoyu Jiao, Ting Li, Jie Wei, Yuxuan Cheng, Wan Zhang, Jun Peng, Aijun Zhang
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引用次数: 0

摘要

免疫性血小板减少症(ITP)是儿童最常见的免疫性出血性疾病。我们的回顾性研究分析了住院的儿科ITP患者,以确定早期治疗反应和长期临床结果的决定因素。研究发现,年龄越小的患儿7天完全缓解(CR)率越高,早期达到CR的可能性越大(p = 0.003,风险比= 0.960[0.934-0.986])。不同剂量静脉注射免疫球蛋白亚组间早期部分缓解率和CR率无差异(p < 0.05)。年龄被确定为影响长期预后的独立因素,年龄较大的儿童患病时间较长
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Early response and long-term prognosis of paediatric ITP: Exploration of future management strategies

Early response and long-term prognosis of paediatric ITP: Exploration of future management strategies

Immune thrombocytopenia (ITP) is the most common immunological haemorrhagic disease in childhood. Our retrospective study analysed hospitalized paediatric ITP patients to identify determinants of early treatment response and long-term clinical outcomes. The study found that younger children had a higher 7-day complete response (CR) rate and were more likely to achieve CR in the early stages (p = 0.003, hazard ratio = 0.960 [0.934–0.986]). There was no difference in early partial response or CR rates between subgroups of intravenous immunoglobulin at different doses (p > 0.05). Age was identified as an independent factor affecting long-term prognosis, with older children experiencing a longer duration of illness (p < 0.001, odds ratio = 1.225 [1.143–1.309]). The long-term prognosis was not influenced by early treatment response. Despite this, current first-line treatments for children cannot prevent disease recurrence or improve long-term outcomes. Whether treatment strategies based on risk stratification and early combination of second-line treatments can decrease glucocorticoid use, reduce the likelihood of chronic ITP, improve quality of life and optimize long-term prognosis remains to be determined. The optimization of treatment regimens based on risk stratification warrants further investigation.

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来源期刊
CiteScore
8.60
自引率
4.60%
发文量
565
审稿时长
1 months
期刊介绍: The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
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