{"title":"在生物模式形成的背景下求解Gierer-Meinhardt (G-M)模型的计算方法","authors":"Nek Muhammad Katbar , Shengjun Liu , Hongjuan Liu","doi":"10.1016/j.jocs.2025.102651","DOIUrl":null,"url":null,"abstract":"<div><div>A mathematical framework with a particular focus on developmental biology can be attained from the Gierer-Meinhardt model, which explains the emergence of spatial patterns within biological systems. These patterns emerge when different chemical substances interact in a complicated manner, following a structured mathematical framework (Gierer-Meinhardt model), which helps explain how these patterns develop over time. The production of animal stripes on the skin and the organization of embryonic development are biological processes that usually involve these patterns. The present study conducts a detailed mathematical analysis of the Gierer-Meinhardt model by incorporating activation function such as radial basis function. The findings of the present study indicate that the radial basis function neural network is an effective tool for analyzing such complex mathematical models. By correlating the well-established biological models with computational tools like the ANN-RBF networks, new opportunities are created for examining the intricacy of living systems, and the foundation for further research in developmental biology and other fields.</div></div>","PeriodicalId":48907,"journal":{"name":"Journal of Computational Science","volume":"90 ","pages":"Article 102651"},"PeriodicalIF":3.1000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A computational approach for solving the Gierer-Meinhardt (G-M) model in the context of biological pattern formation\",\"authors\":\"Nek Muhammad Katbar , Shengjun Liu , Hongjuan Liu\",\"doi\":\"10.1016/j.jocs.2025.102651\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A mathematical framework with a particular focus on developmental biology can be attained from the Gierer-Meinhardt model, which explains the emergence of spatial patterns within biological systems. These patterns emerge when different chemical substances interact in a complicated manner, following a structured mathematical framework (Gierer-Meinhardt model), which helps explain how these patterns develop over time. The production of animal stripes on the skin and the organization of embryonic development are biological processes that usually involve these patterns. The present study conducts a detailed mathematical analysis of the Gierer-Meinhardt model by incorporating activation function such as radial basis function. The findings of the present study indicate that the radial basis function neural network is an effective tool for analyzing such complex mathematical models. By correlating the well-established biological models with computational tools like the ANN-RBF networks, new opportunities are created for examining the intricacy of living systems, and the foundation for further research in developmental biology and other fields.</div></div>\",\"PeriodicalId\":48907,\"journal\":{\"name\":\"Journal of Computational Science\",\"volume\":\"90 \",\"pages\":\"Article 102651\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Computational Science\",\"FirstCategoryId\":\"94\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1877750325001280\",\"RegionNum\":3,\"RegionCategory\":\"计算机科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Computational Science","FirstCategoryId":"94","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877750325001280","RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
A computational approach for solving the Gierer-Meinhardt (G-M) model in the context of biological pattern formation
A mathematical framework with a particular focus on developmental biology can be attained from the Gierer-Meinhardt model, which explains the emergence of spatial patterns within biological systems. These patterns emerge when different chemical substances interact in a complicated manner, following a structured mathematical framework (Gierer-Meinhardt model), which helps explain how these patterns develop over time. The production of animal stripes on the skin and the organization of embryonic development are biological processes that usually involve these patterns. The present study conducts a detailed mathematical analysis of the Gierer-Meinhardt model by incorporating activation function such as radial basis function. The findings of the present study indicate that the radial basis function neural network is an effective tool for analyzing such complex mathematical models. By correlating the well-established biological models with computational tools like the ANN-RBF networks, new opportunities are created for examining the intricacy of living systems, and the foundation for further research in developmental biology and other fields.
期刊介绍:
Computational Science is a rapidly growing multi- and interdisciplinary field that uses advanced computing and data analysis to understand and solve complex problems. It has reached a level of predictive capability that now firmly complements the traditional pillars of experimentation and theory.
The recent advances in experimental techniques such as detectors, on-line sensor networks and high-resolution imaging techniques, have opened up new windows into physical and biological processes at many levels of detail. The resulting data explosion allows for detailed data driven modeling and simulation.
This new discipline in science combines computational thinking, modern computational methods, devices and collateral technologies to address problems far beyond the scope of traditional numerical methods.
Computational science typically unifies three distinct elements:
• Modeling, Algorithms and Simulations (e.g. numerical and non-numerical, discrete and continuous);
• Software developed to solve science (e.g., biological, physical, and social), engineering, medicine, and humanities problems;
• Computer and information science that develops and optimizes the advanced system hardware, software, networking, and data management components (e.g. problem solving environments).