北京健康孕妇抗凝和纤溶指标孕期特异性参考区间的建立

IF 2
Linzi Miao, Xiao Sun, Zijing Zhu, Yuanyuan Li, Yao Lu, Ran You, Chenxue Qu
{"title":"北京健康孕妇抗凝和纤溶指标孕期特异性参考区间的建立","authors":"Linzi Miao, Xiao Sun, Zijing Zhu, Yuanyuan Li, Yao Lu, Ran You, Chenxue Qu","doi":"10.1177/10760296251342456","DOIUrl":null,"url":null,"abstract":"<p><p>ObjectiveContinuously tracking and monitoring the changes in indicators of anticoagulation and fibrinolysis in healthy pregnant women during different pregnancy periods, to establish trimester-specific reference intervals.MethodsA total of 200 healthy pregnant women registered in Peking University First Hospital were enrolled. Venous blood samples were collected at different pregnancy periods, and thirteen related anticoagulation and fibrinolysis indicators were tested. The impact of pregnancy periods on these indicators were analyzed, and corresponding reference intervals were established.ResultsSignificant differences were observed among the non-pregnant group and the first trimester(6-8weeks), second trimester(24-28weeks), and third trimester(36-38weeks) groups for antithrombin (AT), protein S activity (PS Ac), free protein S (FPS), protein C (PC), D-Dimer, fibrin/fibrinogen degradation products (FDP), plasmin inhibitor (PI), plasminogen (PLG), von Willebrand factor activity (vWF:Ac), von Willebrand factor antigen (vWF:Ag), lupus anticoagulant. AT, PS Ac, and FPS showed a downward trend with increasing gestational period. PI was significantly increased in the first trimester. PLG and vWF:Ag was higher in the second trimester and the third trimester. vWF:Ac, D-Dimer and FDP showed an continuously upward trend with increasing gestational period; the normalized SCT ratio (SCT TR)was significantly lower in the third trimester; the normalized dRVVT ratio (dRVVT TR)was significantly higher in the second and third trimester.ConclusionThis study established reference intervals for thirteen anticoagulant and fibrinolytic indicators in healthy pregnant women in Beijing, China. Additionally, pregnancy periods affect the test results of anticoagulant and fibrinolytic indicators in pregnant women, and the reference intervals should be established separately according to pregnancy periods.</p>","PeriodicalId":520590,"journal":{"name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","volume":"31 ","pages":"10760296251342456"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174712/pdf/","citationCount":"0","resultStr":"{\"title\":\"Establishment Trimester-Specific Reference Intervals of Anticoagulation and Fibrinolysis Indicators in Healthy Pregnant Women in Beijing, China.\",\"authors\":\"Linzi Miao, Xiao Sun, Zijing Zhu, Yuanyuan Li, Yao Lu, Ran You, Chenxue Qu\",\"doi\":\"10.1177/10760296251342456\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ObjectiveContinuously tracking and monitoring the changes in indicators of anticoagulation and fibrinolysis in healthy pregnant women during different pregnancy periods, to establish trimester-specific reference intervals.MethodsA total of 200 healthy pregnant women registered in Peking University First Hospital were enrolled. Venous blood samples were collected at different pregnancy periods, and thirteen related anticoagulation and fibrinolysis indicators were tested. The impact of pregnancy periods on these indicators were analyzed, and corresponding reference intervals were established.ResultsSignificant differences were observed among the non-pregnant group and the first trimester(6-8weeks), second trimester(24-28weeks), and third trimester(36-38weeks) groups for antithrombin (AT), protein S activity (PS Ac), free protein S (FPS), protein C (PC), D-Dimer, fibrin/fibrinogen degradation products (FDP), plasmin inhibitor (PI), plasminogen (PLG), von Willebrand factor activity (vWF:Ac), von Willebrand factor antigen (vWF:Ag), lupus anticoagulant. AT, PS Ac, and FPS showed a downward trend with increasing gestational period. PI was significantly increased in the first trimester. PLG and vWF:Ag was higher in the second trimester and the third trimester. vWF:Ac, D-Dimer and FDP showed an continuously upward trend with increasing gestational period; the normalized SCT ratio (SCT TR)was significantly lower in the third trimester; the normalized dRVVT ratio (dRVVT TR)was significantly higher in the second and third trimester.ConclusionThis study established reference intervals for thirteen anticoagulant and fibrinolytic indicators in healthy pregnant women in Beijing, China. Additionally, pregnancy periods affect the test results of anticoagulant and fibrinolytic indicators in pregnant women, and the reference intervals should be established separately according to pregnancy periods.</p>\",\"PeriodicalId\":520590,\"journal\":{\"name\":\"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis\",\"volume\":\"31 \",\"pages\":\"10760296251342456\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174712/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/10760296251342456\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/10760296251342456","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/16 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

目的持续跟踪监测健康孕妇在不同妊娠期抗凝、纤溶指标的变化,建立妊娠期特异性参考区间。方法选取北京大学第一医院登记的健康孕妇200例。采集不同妊娠期静脉血,检测13项相关抗凝、纤溶指标。分析妊娠期对这些指标的影响,建立相应的参考区间。结果非妊娠组在抗凝血酶(AT)、蛋白S活性(PS Ac)、游离蛋白S (FPS)、蛋白C (PC)、d -二聚体、纤维蛋白/纤维蛋白原降解产物(FDP)、纤溶酶抑制剂(PI)、纤溶酶原(PLG)、血管性血友病因子活性(vWF:Ac)、血管性血友病因子抗原(vWF:Ag)、狼疮抗凝血剂等指标上与妊娠前期(6-8周)、妊娠中期(24-28周)、妊娠晚期(36-38周)组差异均有统计学意义。AT、PS、Ac、FPS随妊娠期增加呈下降趋势。PI在妊娠早期显著升高。PLG和vWF:Ag在妊娠中期和晚期较高。vWF:Ac、d -二聚体和FDP随妊娠期增加呈持续上升趋势;标准化SCT比率(SCT TR)在妊娠晚期显著降低;标准化dRVVT比(dRVVT TR)在妊娠中期和晚期显著升高。结论本研究建立了北京健康孕妇13项抗凝血和纤溶指标的参考区间。另外,妊娠期会影响孕妇抗凝血和纤溶指标的检测结果,参照区间应根据妊娠期另行确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Establishment Trimester-Specific Reference Intervals of Anticoagulation and Fibrinolysis Indicators in Healthy Pregnant Women in Beijing, China.

ObjectiveContinuously tracking and monitoring the changes in indicators of anticoagulation and fibrinolysis in healthy pregnant women during different pregnancy periods, to establish trimester-specific reference intervals.MethodsA total of 200 healthy pregnant women registered in Peking University First Hospital were enrolled. Venous blood samples were collected at different pregnancy periods, and thirteen related anticoagulation and fibrinolysis indicators were tested. The impact of pregnancy periods on these indicators were analyzed, and corresponding reference intervals were established.ResultsSignificant differences were observed among the non-pregnant group and the first trimester(6-8weeks), second trimester(24-28weeks), and third trimester(36-38weeks) groups for antithrombin (AT), protein S activity (PS Ac), free protein S (FPS), protein C (PC), D-Dimer, fibrin/fibrinogen degradation products (FDP), plasmin inhibitor (PI), plasminogen (PLG), von Willebrand factor activity (vWF:Ac), von Willebrand factor antigen (vWF:Ag), lupus anticoagulant. AT, PS Ac, and FPS showed a downward trend with increasing gestational period. PI was significantly increased in the first trimester. PLG and vWF:Ag was higher in the second trimester and the third trimester. vWF:Ac, D-Dimer and FDP showed an continuously upward trend with increasing gestational period; the normalized SCT ratio (SCT TR)was significantly lower in the third trimester; the normalized dRVVT ratio (dRVVT TR)was significantly higher in the second and third trimester.ConclusionThis study established reference intervals for thirteen anticoagulant and fibrinolytic indicators in healthy pregnant women in Beijing, China. Additionally, pregnancy periods affect the test results of anticoagulant and fibrinolytic indicators in pregnant women, and the reference intervals should be established separately according to pregnancy periods.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信