Rebeca Ferreira Dias, Sarah de Lima Silva, Sophia Parreira de Mello, Lucinar Jupir Forner Flores, Márcia Rosângela Buzanello, Gladson Ricardo Flor Bertolini
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The primary outcome was pain, while secondary outcomes included functionality and muscle strength.</p><p><strong>Results: </strong>Five randomized controlled trials were selected from 2094 initial registrations. The meta-analysis included all five studies in the pain intensity outcome, resulting in a standardized mean difference (SMD) of -0.57 (95% CI: [-0.97, -0.18]; p = 0.004; I<sup>2</sup> = 42%). In addition, four studies were included in the functionality outcome, with an SMD of -0.28 (95% CI: [-0.58, 0.02]; p = 0.07; I<sup>2</sup> = 0%). Only one study assessed muscle strength.</p><p><strong>Conclusion: </strong>These findings indicate that cryotherapy can be useful as part of a comprehensive treatment for knee osteoarthritis, especially when combined with kinesiotherapy, but its effectiveness as a stand-alone treatment still requires further studies with a lower risk of bias.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":"25 6","pages":"e70055"},"PeriodicalIF":2.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168428/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cryotherapy in Knee Osteoarthritis: A Systematic Review With Meta-Analysis.\",\"authors\":\"Rebeca Ferreira Dias, Sarah de Lima Silva, Sophia Parreira de Mello, Lucinar Jupir Forner Flores, Márcia Rosângela Buzanello, Gladson Ricardo Flor Bertolini\",\"doi\":\"10.1111/papr.70055\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To update knowledge on the effects of cryotherapy in reducing pain, increasing strength, and improving function in patients with knee osteoarthritis.</p><p><strong>Methods: </strong>The databases used included PubMed, Embase, Cochrane, Physiotherapy Evidence Database (PEDro), Scopus, Web of Science, and LILACS. In addition, gray literature was searched in Google Scholar, LIVIVO, Open Gray, and the CAPES Library of Theses and Dissertations. The risk of bias was assessed using the Cochrane tool, RoB 2, by two independent reviewers, with conflicts being resolved by consensus. The primary outcome was pain, while secondary outcomes included functionality and muscle strength.</p><p><strong>Results: </strong>Five randomized controlled trials were selected from 2094 initial registrations. The meta-analysis included all five studies in the pain intensity outcome, resulting in a standardized mean difference (SMD) of -0.57 (95% CI: [-0.97, -0.18]; p = 0.004; I<sup>2</sup> = 42%). In addition, four studies were included in the functionality outcome, with an SMD of -0.28 (95% CI: [-0.58, 0.02]; p = 0.07; I<sup>2</sup> = 0%). Only one study assessed muscle strength.</p><p><strong>Conclusion: </strong>These findings indicate that cryotherapy can be useful as part of a comprehensive treatment for knee osteoarthritis, especially when combined with kinesiotherapy, but its effectiveness as a stand-alone treatment still requires further studies with a lower risk of bias.</p>\",\"PeriodicalId\":19974,\"journal\":{\"name\":\"Pain Practice\",\"volume\":\"25 6\",\"pages\":\"e70055\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168428/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pain Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/papr.70055\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ANESTHESIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/papr.70055","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
Cryotherapy in Knee Osteoarthritis: A Systematic Review With Meta-Analysis.
Objective: To update knowledge on the effects of cryotherapy in reducing pain, increasing strength, and improving function in patients with knee osteoarthritis.
Methods: The databases used included PubMed, Embase, Cochrane, Physiotherapy Evidence Database (PEDro), Scopus, Web of Science, and LILACS. In addition, gray literature was searched in Google Scholar, LIVIVO, Open Gray, and the CAPES Library of Theses and Dissertations. The risk of bias was assessed using the Cochrane tool, RoB 2, by two independent reviewers, with conflicts being resolved by consensus. The primary outcome was pain, while secondary outcomes included functionality and muscle strength.
Results: Five randomized controlled trials were selected from 2094 initial registrations. The meta-analysis included all five studies in the pain intensity outcome, resulting in a standardized mean difference (SMD) of -0.57 (95% CI: [-0.97, -0.18]; p = 0.004; I2 = 42%). In addition, four studies were included in the functionality outcome, with an SMD of -0.28 (95% CI: [-0.58, 0.02]; p = 0.07; I2 = 0%). Only one study assessed muscle strength.
Conclusion: These findings indicate that cryotherapy can be useful as part of a comprehensive treatment for knee osteoarthritis, especially when combined with kinesiotherapy, but its effectiveness as a stand-alone treatment still requires further studies with a lower risk of bias.
期刊介绍：
Pain Practice, the official journal of the World Institute of Pain, publishes international multidisciplinary articles on pain and analgesia that provide its readership with up-to-date research, evaluation methods, and techniques for pain management. Special sections including the Consultant’s Corner, Images in Pain Practice, Case Studies from Mayo, Tutorials, and the Evidence-Based Medicine combine to give pain researchers, pain clinicians and pain fellows in training a systematic approach to continuing education in pain medicine. Prior to publication, all articles and reviews undergo peer review by at least two experts in the field.
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