Khushi H Shah, Adham M Khalafallah, Maxon V Knott, Chandler N Berke, Christian K Ramsoomair, Victor M Lu, Michael E Ivan, Ricardo J Komotar, Ashish H Shah
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Bivariate statistical analyses included Fisher's exact test, chi-square test, and t-tests. Univariate and multivariate logistic regression identified significant predictors of pLOS.</p><p><strong>Results: </strong>Of 294 patients in this study, 73 patients in the study group (mean age 62.14 ± 11.63 years, 54.8% males) with a median LOS of 4.12 [IQR: 3.01-6.67] days were compared to 221 controls (mean age 59.50 ± 14.01 years, 40.3% males) with a median LOS of 1.92 [IQR: 1.86-2.01] days. Upon multivariate analysis, higher mFI-5 scores (OR 1.80; 95% CI [1.31-2.47]; p < 0.001), preoperative neurologic deficits (OR 2.27; 95% CI [1.09-4.76]; p = 0.029), and preoperative tumor volume (OR 2.03; 95% CI [1.46-2.83]; p < 0.001) were significantly associated with pLOS. Operative time, number of pullbacks, and extent of ablation were not significantly associated with pLOS (p > 0.05).</p><p><strong>Conclusion: </strong>To our knowledge, this is the first study to identify preoperative mFI-5 score, neurological deficit, and tumor volume as independent predictors of pLOS in patients undergoing LITT for intracranial pathologies.</p>","PeriodicalId":16425,"journal":{"name":"Journal of Neuro-Oncology","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Predictors of prolonged length of stay in patients undergoing laser interstitial thermal therapy for intracranial tumors.\",\"authors\":\"Khushi H Shah, Adham M Khalafallah, Maxon V Knott, Chandler N Berke, Christian K Ramsoomair, Victor M Lu, Michael E Ivan, Ricardo J Komotar, Ashish H Shah\",\"doi\":\"10.1007/s11060-025-05101-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Laser interstitial thermal therapy (LITT) offers a minimally invasive approach for treating intracranial pathologies while offering shorter length of stays (LOS) as compared to traditional craniotomies. 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引用次数: 0
摘要
目的:与传统开颅手术相比,激光间质热治疗(LITT)提供了一种微创治疗颅内病变的方法,同时提供了更短的住院时间(LOS)。然而,一些患者仍然面临延长的LOS (pLOS),强调需要确定影响pLOS的因素以改善结果。方法:回顾性分析我院2012年至2023年因颅内病变接受LITT治疗的患者。结果:本研究294例患者中,研究组73例患者(平均年龄62.14±11.63岁,男性54.8%)的中位LOS为4.12 [IQR: 3.01-6.67]天,对照组221例患者(平均年龄59.50±14.01岁,男性40.3%)的中位LOS为1.92 [IQR: 1.86-2.01]天。多因素分析显示,mFI-5评分越高(OR 1.80;95% ci [1.31-2.47];p 0.05)。结论:据我们所知,这是第一个确定术前mFI-5评分、神经功能缺损和肿瘤体积作为颅内病理行LITT患者pLOS独立预测因子的研究。
Predictors of prolonged length of stay in patients undergoing laser interstitial thermal therapy for intracranial tumors.
Purpose: Laser interstitial thermal therapy (LITT) offers a minimally invasive approach for treating intracranial pathologies while offering shorter length of stays (LOS) as compared to traditional craniotomies. Yet, some patients still face prolonged LOS (pLOS), highlighting the need to identify factors contributing to pLOS to improve outcomes.
Methods: We retrospectively reviewed patients who underwent LITT for intracranial pathologies at our institution from 2012 to 2023. Patients with LOS ≥ 75th percentile formed the study group, while those with LOS < 75th percentile formed control group. Patient demographics and perioperative factors were analyzed. Bivariate statistical analyses included Fisher's exact test, chi-square test, and t-tests. Univariate and multivariate logistic regression identified significant predictors of pLOS.
Results: Of 294 patients in this study, 73 patients in the study group (mean age 62.14 ± 11.63 years, 54.8% males) with a median LOS of 4.12 [IQR: 3.01-6.67] days were compared to 221 controls (mean age 59.50 ± 14.01 years, 40.3% males) with a median LOS of 1.92 [IQR: 1.86-2.01] days. Upon multivariate analysis, higher mFI-5 scores (OR 1.80; 95% CI [1.31-2.47]; p < 0.001), preoperative neurologic deficits (OR 2.27; 95% CI [1.09-4.76]; p = 0.029), and preoperative tumor volume (OR 2.03; 95% CI [1.46-2.83]; p < 0.001) were significantly associated with pLOS. Operative time, number of pullbacks, and extent of ablation were not significantly associated with pLOS (p > 0.05).
Conclusion: To our knowledge, this is the first study to identify preoperative mFI-5 score, neurological deficit, and tumor volume as independent predictors of pLOS in patients undergoing LITT for intracranial pathologies.
期刊介绍:
The Journal of Neuro-Oncology is a multi-disciplinary journal encompassing basic, applied, and clinical investigations in all research areas as they relate to cancer and the central nervous system. It provides a single forum for communication among neurologists, neurosurgeons, radiotherapists, medical oncologists, neuropathologists, neurodiagnosticians, and laboratory-based oncologists conducting relevant research. The Journal of Neuro-Oncology does not seek to isolate the field, but rather to focus the efforts of many disciplines in one publication through a format which pulls together these diverse interests. More than any other field of oncology, cancer of the central nervous system requires multi-disciplinary approaches. To alleviate having to scan dozens of journals of cell biology, pathology, laboratory and clinical endeavours, JNO is a periodical in which current, high-quality, relevant research in all aspects of neuro-oncology may be found.