ROR1在卵巢癌患者中的表达及其与化疗反应和预后的关系

IF 0.9 Q4 ONCOLOGY
International journal of clinical and experimental pathology Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI:10.62347/EHAI6164
Yan Zhang, Wei Wang, Lian Xu, Liujing Huang, Tian Qin, Ling Kang, Qin Huang
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引用次数: 0

摘要

目的:探讨受体酪氨酸激酶样孤儿受体1 (ROR1)在卵巢癌组织中的表达及其与卵巢癌患者临床病理特征、化疗敏感性及预后的关系。方法:采集227例卵巢癌患者石蜡组织块,免疫组化(IHC)染色分析ROR1的表达。评估ROR1表达与临床病理特征、治疗反应和预后之间的关系。结果:ROR1表达与肿瘤负荷:在卵巢癌患者中,ROR1的高表达与较重的肿瘤负荷相关。ROR1与化疗:与首次减容手术(PDS)和后续化疗(SSC)相比,行间歇减容手术(IDS)患者的ROR1表达明显升高。这表明化疗可能促进肿瘤组织中ROR1表达的增加。此外,在铂敏感患者中观察到ROR1表达升高的趋势。透明细胞卵巢癌核表达:在透明细胞卵巢癌中意外检测到ROR1核表达阳性,提示ROR1核易位与不良预后有关。结论:ROR1表达可能与卵巢癌患者的治疗策略及铂类化疗史有关。靶向ROR1可能是治疗卵巢癌的一种有前景的治疗策略。需要进一步的研究来阐明ROR1核易位在预后中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ROR1 expression in ovarian cancer patients and its association with chemotherapy response and prognosis.

Objective: To investigate the expression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) in ovarian cancer tissues and its correlation with clinicopathologic features, chemotherapy sensitivity, and prognosis in patients with ovarian cancer.

Methods: Paraffin tissue blocks were collected from 227 ovarian cancer patients, and immunohistochemical (IHC) staining was performed to analyze the expression of ROR1. The associations between ROR1 expression and clinicopathologic features, treatment response, and prognosis were evaluated.

Results: ROR1 expression and tumor load: higher expression of ROR1 was associated with a heavier tumor load in ovarian cancer patients. ROR1 and chemotherapy: the expression of ROR1 was significantly higher in patients who underwent interval debulking surgery (IDS) compared to primary debulking surgery (PDS) and subsequent chemotherapy (SSC). This suggests that chemotherapy may promote increased ROR1 expression in tumor tissues. Additionally, a trend of higher ROR1 expression was observed in platinum-sensitive patients. Nuclear expression in clear cell ovarian cancer: positive nuclear expression of ROR1 was unexpectedly detected in clear cell ovarian cancer, suggesting a link between ROR1 nuclear translocation and poor prognosis.

Conclusion: ROR1 expression may be related to treatment strategy and history of platinum-based chemotherapy in ovarian cancer patients. Targeting ROR1 could represent a promising therapeutic strategy for the treatment of ovarian cancer. Further studies are needed to elucidate the role of ROR1 nuclear translocation in prognosis.

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来源期刊
自引率
0.00%
发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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