炎性肠病色镜检查异常增生术后肿瘤的病理发生率。

IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY
Crohn's & Colitis 360 Pub Date : 2025-06-05 eCollection Date: 2025-04-01 DOI:10.1093/crocol/otaf032
Talal Dahab, Luca Stocchi, Amit Merchea, Dorin T Colibaseanu, Francis A Farraye, Kelly L Mathis, David A Etzioni, David H Bruining, Michael F Picco
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引用次数: 0

摘要

简介:本研究的目的是探讨在炎性肠病(IBD)的色内窥镜(CE)监测中发现的不典型增生手术患者的特征和手术标本中癌症的发生率。方法:回顾性分析2006年至2019年在三站点企业三级转诊中心通过CE诊断为潜在IBD背景的所有发育不良患者的医疗记录。我们的目的是评估需要手术治疗不典型增生患者的临床特征和手术标本中癌症的发生率。结果:219例CE异常增生患者中,35例(16%)接受了手术治疗。手术指征为多灶性病变(n = 6)、内镜下不可切除病变(n = 13)、可见HGD (n = 7)和单灶性不可见LGD (n = 9)。在35例需要手术的患者中,5例发现患有腺癌,其中1例IIIB期患者接受了术后化疗。术后平均随访32个月,病理诊断为腺癌的患者无复发迹象。结论:虽然ibd相关发育不良患者手术时的癌症发生率不容忽视,但淋巴结阳性疾病的发生率较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathologic Rate of Cancer After Surgery for Dysplasia Detected on Chromoendoscopy for Inflammatory Bowel Disease.

Introduction: The objective of the study was to investigate the characteristics of patients who underwent surgery for dysplasia detected during chromoendoscopy (CE) surveillance for inflammatory bowel disease (IBD) and the incidence of cancer in the surgical specimen.

Methods: A retrospective review of medical records of all patients with dysplasia on a background of underlying IBD diagnosed through CE was carried out at a tri-site enterprise tertiary referral center between 2006 and 2019. We aimed to assess the clinical characteristics of patients requiring surgery for dysplasia and the incidence of cancer in the surgical specimen.

Results: Out of 219 patients with dysplasia on CE, 35 underwent surgery for dysplasia (16%). Indications for surgery were multifocal disease (n = 6), endoscopically unresectable lesions (n = 13), visible HGD (n = 7) and unifocal invisible LGD (n = 9). Out of 35 patients requiring surgery, 5 were found to have adenocarcinoma, one of whom with stage IIIB disease received postoperative chemotherapy. No patient with a pathologic diagnosis of adenocarcinoma had any evidence of recurrent disease after a mean postoperative follow-up of 32 months.

Conclusions: While the incidence of cancer at the time of surgery for IBD-related dysplasia is not negligible, the rate of node-positive disease is low.

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来源期刊
Crohn's & Colitis 360
Crohn's & Colitis 360 Medicine-Gastroenterology
CiteScore
2.50
自引率
0.00%
发文量
41
审稿时长
12 weeks
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