Carol Park, Douglas R. Nordli III, Mohamed Taha, Henry David, Shawn Kacker, Tareq Kass-Hout, Sonam Thind, Aurelie Hanin, Sana Said, Hiba A. Haider, Douglas R. Nordli Jr.
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Advancing FIRES Treatment: The Potential of Intrathecal Dexamethasone
Background
Febrile infection-related epilepsy syndrome (FIRES) is a rare, devastating epilepsy syndrome characterized by refractory status epilepticus following a febrile illness.
Patient Description
We describe a 12-year-old girl with FIRES who exhibited a remarkable clinical and electrographic response to intrathecal dexamethasone (IT-DEX) after failing multiple antiseizure and immunomodulatory therapies. Despite persistent neuroinflammation, IT-DEX led to rapid seizure control and significant neurological recovery.
Conclusion
This report supports IT-DEX as a promising intervention in FIRES and underscores the need for further research into its mechanisms and long-term efficacy.
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