扩展外离子注入到离子阱/TOFMS: SIMION分析的m/z范围

IF 1.9 3区 化学 Q3 BIOCHEMICAL RESEARCH METHODS
Yixue Cao, Ping Chen, Xuesong Zhang, Yuanyuan Xie, Lichuan Zhang, Chenxin Wu, Lei Hua, Haiyang Li
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引用次数: 0

摘要

离子阱通常作为离子阱飞行时间质谱仪(IT/TOF)的TOF推子区,实现了高占空比、MS/MS能力和高质量分辨率的优点。虽然较短的离子阱杆长度提高了TOF的分辨率,但它限制了同轴it /TOF的质量范围。通过基于SIMION仿真的计算研究,系统地研究了几何参数(阱杆长度)和电压参数(偏置直流电压、端盖电极电压)对同轴IT-TOF系统质量范围的影响。通过优化捕集棒的长度,在不牺牲质量分辨率的情况下,在m/z 400-1400范围内实现了90%以上的注入效率。通过对低m/z离子进行直流偏置电压调整,对高m/z离子在端盖电极上进行阶跃电压优化,模拟质量范围扩展到m/z 200-1400,质量偏差最小。以上结论都是通过仿真分析得出的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extend m/z Range of External Ion Injection Into Ion Trap/TOFMS: SIMION Analysis

Ion trap usually serves as a TOF pusher region in ion trap time-of-flight mass spectrometer (IT/TOF), achieving benefits of high duty cycle, MS/MS capability, and high mass resolution. While a short ion trap rod length improves TOF resolution, it limits the mass range in coaxial IT/TOF. Through a computational study based on SIMION simulations, this work systematically investigates the influence of geometric parameters (trap rod length) and voltage parameters (bias DC voltage, end-cap electrode voltage) on the mass range of coaxial IT-TOF systems. By optimizing length of trap rod, over 90% injection efficiency was achieved within a m/z 400–1400 without sacrificing mass resolution. By implementing DC bias voltage adjustments for low-m/z ions and step voltage optimization on end-cap electrodes for high-m/z ions, the simulated mass range is extended to m/z 200–1400 with minimal mass discrimination. All above these findings are derived solely from simulation analysis.

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来源期刊
Journal of Mass Spectrometry
Journal of Mass Spectrometry 化学-光谱学
CiteScore
5.10
自引率
0.00%
发文量
84
审稿时长
1.5 months
期刊介绍: The Journal of Mass Spectrometry publishes papers on a broad range of topics of interest to scientists working in both fundamental and applied areas involving the study of gaseous ions. The aim of JMS is to serve the scientific community with information provided and arranged to help senior investigators to better stay abreast of new discoveries and studies in their own field, to make them aware of events and developments in associated fields, and to provide students and newcomers the basic tools with which to learn fundamental and applied aspects of mass spectrometry.
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