{"title":"芬氟拉明:尿药检假阳性的罕见原因:1例报告","authors":"Maria Ghawji, Meagan Hainlen, Charuta Joshi","doi":"10.1002/cns3.70012","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Fenfluramine is an antiseizure medication approved by the Food and Drug Administration for the treatment of Dravet syndrome in patients older than 2 years. Fenfluramine is an amphetamine derivative. It cross-reacts with amphetamines in urine drug screen immunoassays.</p>\n </section>\n \n <section>\n \n <h3> Patient Presentation</h3>\n \n <p>A 2-year-old patient with Dravet syndrome had a cardiorespiratory arrest and tested positive for amphetamines in a urine drug screen, raising concerns of child abuse. Liquid chromatography–mass spectrometry confirmed the presence of fenfluramine but did not detect amphetamines.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Fenfluramine can result in a false-positive amphetamine urine drug screen at the recommended dose for Dravet syndrome. Awareness of this potential cross-reactivity can prevent undue child protective services reports, especially in patients at high risk for sudden death.</p>\n </section>\n </div>","PeriodicalId":72232,"journal":{"name":"Annals of the Child Neurology Society","volume":"3 2","pages":"121-124"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cns3.70012","citationCount":"0","resultStr":"{\"title\":\"Fenfluramine: An Uncommon Cause of False Positive Urine Drug Testing: A Case Report\",\"authors\":\"Maria Ghawji, Meagan Hainlen, Charuta Joshi\",\"doi\":\"10.1002/cns3.70012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Fenfluramine is an antiseizure medication approved by the Food and Drug Administration for the treatment of Dravet syndrome in patients older than 2 years. Fenfluramine is an amphetamine derivative. It cross-reacts with amphetamines in urine drug screen immunoassays.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Patient Presentation</h3>\\n \\n <p>A 2-year-old patient with Dravet syndrome had a cardiorespiratory arrest and tested positive for amphetamines in a urine drug screen, raising concerns of child abuse. Liquid chromatography–mass spectrometry confirmed the presence of fenfluramine but did not detect amphetamines.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Fenfluramine can result in a false-positive amphetamine urine drug screen at the recommended dose for Dravet syndrome. Awareness of this potential cross-reactivity can prevent undue child protective services reports, especially in patients at high risk for sudden death.</p>\\n </section>\\n </div>\",\"PeriodicalId\":72232,\"journal\":{\"name\":\"Annals of the Child Neurology Society\",\"volume\":\"3 2\",\"pages\":\"121-124\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cns3.70012\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of the Child Neurology Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cns3.70012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of the Child Neurology Society","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cns3.70012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Fenfluramine: An Uncommon Cause of False Positive Urine Drug Testing: A Case Report
Background
Fenfluramine is an antiseizure medication approved by the Food and Drug Administration for the treatment of Dravet syndrome in patients older than 2 years. Fenfluramine is an amphetamine derivative. It cross-reacts with amphetamines in urine drug screen immunoassays.
Patient Presentation
A 2-year-old patient with Dravet syndrome had a cardiorespiratory arrest and tested positive for amphetamines in a urine drug screen, raising concerns of child abuse. Liquid chromatography–mass spectrometry confirmed the presence of fenfluramine but did not detect amphetamines.
Conclusion
Fenfluramine can result in a false-positive amphetamine urine drug screen at the recommended dose for Dravet syndrome. Awareness of this potential cross-reactivity can prevent undue child protective services reports, especially in patients at high risk for sudden death.