揭示甘草解毒成分及其机制：传统与现代临床观点

IF 5.4 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of ethnopharmacology Pub Date : 2025-06-14 DOI:10.1016/j.jep.2025.120154

Jie Dong , Gang Tian , Qiongfang Xu , Wenli Jiang , Ruina Liu , Jingqi Han , Yu Xiong , Bo Zhu , Qiyuan Shan , Gang Cao

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引用次数: 0

摘要

民族药理学相关性eglycyrrhizae Radix et Rhizoma （GRR）是一种广泛使用的中草药，以其解毒特性而闻名。GRR在降低中西医有害物质和药物的毒性作用方面发挥着重要作用。本文从传统和现代临床角度对GRR的解毒成分和机制进行了综述。材料与方法检索PubMed、Web of Science和CNKI数据库，检索截止到2024年12月31日已发表或访问的文献。关键词“甘草解毒”、“甘草加工”、“甘草相容性”等进行筛选。此外，还收集了中医经典文献中的信息。结果grr调和药性和降低毒性的能力得到历史使用和新出现的药理学证据的支持。在中医中，甘草的甜味和中性是与其他草药加工或配药解毒和协调的关键。从现代药理学角度看，GRR提取物及其生物活性成分在体内和体外均表现出显著的解毒作用。GRR的解毒主要包括物理和化学解毒机制，以及通过肠道菌群、I-III期代谢和免疫调节的药代动力学（PK）和药效学（PD）调节的生物解毒机制。结论通过经典理论与现代科学证据的结合，进一步了解GRR在协调各种化合物的药性和减轻毒性方面的作用，为GRR的进一步开发和药理利用提供理论基础和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Unveiling the detoxification components and mechanisms of glycyrrhizae radix et rhizoma: Traditional and modern clinical perspectives

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Unveiling the detoxification components and mechanisms of glycyrrhizae radix et rhizoma: Traditional and modern clinical perspectives

Ethnopharmacological relevance

Glycyrrhizae Radix et Rhizoma (GRR), is a widely used herbal medicines in traditional Chinese medicine (TCM) known for its detoxification properties. GRR plays a significant role in reducing the toxic effects of harmful substances and drugs in both TCM and Western medicine.

Aim of the study

This review investigates the detoxification components and mechanisms of GRR from both traditional and modern clinical perspectives.

Materials and methods

Literature published or earlier accessed up to December 31, 2024 was searched from PubMed, Web of Science and CNKI databases. Keywords “licorice detoxification”, “licorice processing”, “licorice compatibility”, etc., were used for screening. In addition, information from TCM classic texts was collected.

Results

GRR's ability to harmonize medicinal properties and reduce toxicity is supported by both historical usage and emerging pharmacological evidence. In TCM, the sweet flavor and neutral nature of GRR are the key points to processed or prescribed with other herbs for detoxification and harmonization. From modern pharmacological view, the extracts of GRR and its bioactive components, exhibit significant detoxification effects both in vivo and in vitro. The detoxification of GRR primarily involve physical and chemical detoxification mechanisms, and biological detoxification by pharmacokinetics (PK) and pharmacodynamics (PD) modulations via gut microbiota, phase I-III metabolism, as well as immune regulations.

Conclusion

By integrating classical theory with contemporary scientific evidence, we seek to advance the understanding of GRR's role in harmonizing medicinal properties and mitigating the toxicity of various compounds, to provide a theoretical foundation and insights for the further development and pharmacological utilization of GRR.

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来源期刊

Journal of ethnopharmacology 医学-全科医学与补充医学

CiteScore

10.30

自引率

5.60%

发文量

967

审稿时长

77 days

期刊介绍： The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.