抗生素耐药基因的分子进化和起源

IF 3 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sevan Gholipour, Dongkyu Lee and Nobuhiko Tokuriki*, 
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引用次数: 0

摘要

抗生素耐药性是一种全球性的健康危机,细菌对天然和合成抗生素都有耐药性。虽然所有种类的抗生素都面临类似的机制和进化力量,但它们的起源形成了不同的耐药途径。经过数百万年的生产,天然抗生素推动了抗生素耐药基因(ARGs)的早期出现和共同进化,后来随着临床使用而传播。相比之下,合成抗生素一开始没有预先存在的ARGs,但细菌很快就适应了新的方法来克服它们。从这个角度来看,我们研究了ARG进化的最新发现,包括它们在环境细菌中的分布,宿主范围,以及ARG对细菌适应这些抗生素的潜在分子机制。为了解决这些问题,我们强调迫切需要进行全面的研究,以揭示ARGs的全范围、分布和演化。了解这些过程不仅有助于制定有效的策略来对抗ARGs,而且还为蛋白质化学和蛋白质工程方法的发展提供了重要的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Molecular Evolution and Origins of Antibiotic Resistance Genes

Molecular Evolution and Origins of Antibiotic Resistance Genes

Antibiotic resistance is a global health crisis with bacteria resisting both natural and synthetic antibiotics. While all antibiotic classes face similar mechanistic and evolutionary forces, their origins shape distinct resistance pathways. Produced over millions of years, natural antibiotics drove the early emergence and coevolution of antibiotic resistance genes (ARGs), later spreading with clinical use. By contrast, synthetic antibiotics began without pre-existing ARGs, yet bacteria soon adapted novel approaches to overcome them. In this perspective, we examine recent findings on ARG evolution, including their distribution in environmental bacteria, host range, and underlying molecular mechanisms of ARGs for bacterial adaptation against these antibiotics. To address these questions, we emphasize the urgent need for comprehensive studies to uncover the full range, distribution, and evolution of ARGs. Understanding these processes not only aids in developing effective strategies to combat ARGs but also provides critical insights into protein chemistry and advances protein engineering approaches.

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来源期刊
Biochemistry Biochemistry
Biochemistry Biochemistry 生物-生化与分子生物学
CiteScore
5.50
自引率
3.40%
发文量
336
审稿时长
1-2 weeks
期刊介绍: Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Biochemistry also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.
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