Rh（III）催化3-芳基异吲哚酮与2-甲基三亚甲基碳酸酯通过C-H活化[3 + 4]环化制备异吲哚酮螺苯并西平

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-13 DOI:10.1021/acs.orglett.5c01573

Hai-Shan Jin, Yan Wang, Ru-Jie Zhang and Li-Ming Zhao*,

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引用次数: 0

摘要

研究了Rh（III）催化3-芳基-3-羟基异吲哚酮与2-甲基三亚甲基碳酸酯的碳氢活化/环化反应。该方法通过顺序的C-C和C-O键合成了七元异吲哚酮螺苯并西平，这是药物发现中有趣的支架。它的合成应用也被证明是突出的多功能性。此外，这是第一个在过渡金属催化的C-H活化反应中，2-甲基三亚甲基碳酸酯作为C3O1合成子实现[3 + 4]环化的例子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rh(III)-Catalyzed [3 + 4] Annulation of 3-Arylisoindolinones with 2-Methylidenetrimethylene Carbonate via C–H Activation to Access Isoindolinone Spirobenzoxepines

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Rh(III)-Catalyzed [3 + 4] Annulation of 3-Arylisoindolinones with 2-Methylidenetrimethylene Carbonate via C–H Activation to Access Isoindolinone Spirobenzoxepines

A Rh(III)-catalyzed C–H activation/annulation of 3-aryl-3-hydroxyisoindolinones with 2-methylidenetrimethylene carbonate has been developed. This method leads to the synthesis of seven-membered isoindolinone spirobenzoxepines through sequential C–C and C–O bond formations, which are interesting scaffolds in drug discovery. Its synthetic application has also been demonstrated to highlight the versatility. In addition, this is the first example in which 2-methylidenetrimethylene carbonate serves as a C3O1 synthon to accomplish [3 + 4] annulation in transition-metal-catalyzed C–H activation reactions.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.