pd催化不对称[2 + 4]环化对映选择性合成四氢蒽醌类化合物

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-14 DOI:10.1021/acs.orglett.5c01901

Yumeng Wang, Hongjia Xie, Heping Li, Weijun Yao, Zhen Wang

引用次数: 0

摘要

用手性双膦-萘酰胺/钯络合物促进了2-烷基-3-羟基萘-1,4-二酮与缺电子烯丙基碳酸酯的高效[2 + 4]不对称环化反应。该方法适用于广泛的底物，能够合成具有高立体选择性的具有两个连续的四氢蒽醌类四氢蒽醌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Enantioselective Synthesis of Tetrahydroanthraquinones via Pd-Catalyzed Asymmetric [2 + 4] Annulation

查看原文本刊更多论文

Enantioselective Synthesis of Tetrahydroanthraquinones via Pd-Catalyzed Asymmetric [2 + 4] Annulation

An efficient asymmetric [2 + 4] annulation of 2-alkyl-3-hydroxynaphthalene-1,4-diones with electron-deficient allylic carbonates, promoted by a chiral bisphosphino-naphthamide/palladium complex, has been developed for the first time. This method accommodates a broad range of substrates, enabling the synthesis of tetrahydroanthraquinones bearing two contiguous quaternary stereocenters with high stereoselectivity.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.