481-P：慢性肾脏疾病增加糖尿病视网膜病变患者痴呆风险——一项基于韩国国家健康信息数据的研究

IF 7.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2025-06-13 DOI:10.2337/db25-481-p

NA HYUN SONG, YEONSOO PARK, MIN KYONG MOON

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引用次数: 0

摘要

简介与目的：糖尿病（DM）及其并发症是全球性的健康问题。痴呆症在老年人中引起大量发病率和死亡率，已被证明与糖尿病视网膜病变（DR）和慢性肾脏疾病（CKD）有关。然而，这些情况对痴呆症风险的综合影响尚不清楚。本研究旨在探讨DR和CKD对痴呆风险的个体和联合影响。方法：使用韩国国民健康保险服务国家数据库，纳入2015 - 2016年接受常规健康检查的40岁及以上糖尿病患者2356298例。平均随访时间为5.63年。痴呆发病率采用国际疾病分类第十版修订代码（ICD-10）定义。Cox比例风险分析用于计算CKD或DR患者痴呆的风险比（HR），校正协变量如年龄、性别、BMI、收入、吸烟、饮酒和合并症。结果：CKD患者痴呆的发病率（IR）增加（HR 1.16, 95% CI: 1.15-1.18）。同样，DR患者与非DR患者相比，痴呆风险更高，增殖性糖尿病视网膜病变（PDR）的HR更高，为1.26 (95% CI: 1.21-1.31)，而非PDR患者的HR为1.09 （95% CI: 1.08-1.10）。此外，CKD增加了DR患者痴呆的风险。与无CKD或DR患者相比，CKD和PDR患者的HR为1.57 (95% CI 1.49-1.64)，高于无CKD的PDR患者的HR （HR 1.26, 95% CI 1.21-1.31）。亚组分析显示，在同一疾病组中，年轻患者（40-64岁）的hr高于老年患者（≥65岁）。结论：本研究提示DR患者CKD与痴呆风险的协同作用，强调对糖尿病相关并发症的早期筛查和综合护理的必要性。宋：没有。朴槿惠：没有。文在寅：没有。

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481-P: Chronic Kidney Disease Amplifies Dementia Risk in Patients with Diabetic Retinopathy—A Korean National Health Information Data-Based Study

Introduction and Objective: Diabetes mellitus (DM) and its complications are global health problem. Dementia, which also causes substantial morbidity and mortality among the elderly, has been shown to be associated with diabetic retinopathy (DR) and chronic kidney disease (CKD). However, the combined impact of these conditions on dementia risk remains unclear. This study aims to investigate the individual and combined effects of DR and CKD on dementia risk. Methods: Using the nationwide database of National Health Insurance Service in South Korea, 2,356,298 patients aged 40 years or older with diabetes who underwent routine health examination from 2015 to 2016 were included. The mean follow-up duration was 5.63 years. Dementia incidence was defined using International Classification of Diseases 10th revision codes (ICD-10). Cox proportional hazards analysis was used to calculate hazard ratios (HR) of dementia in patients with CKD or DR, adjusting for covariates such as age, sex, BMI, income, smoking, alcohol consumption, and comorbidities. Results: The incidence rate (IR) of dementia was increased in patients with CKD (HR 1.16, 95% CI: 1.15-1.18). Similarly, DR patients showed higher dementia risk compared to non-DR patients, with proliferative diabetic retinopathy (PDR) associated with higher HR of 1.26 (95% CI: 1.21-1.31) compared to 1.09 (95% CI 1.08-1.10) in non-PDR patients. Furthermore, CKD amplified dementia risk in DR patients. Compared to patients without CKD or DR, patients with CKD and PDR had an HR of 1.57 (95% CI 1.49-1.64), higher than the HR in PDR patients without CKD (HR 1.26, 95% CI 1.21-1.31). Subgroup analysis showed that younger patients (age 40-64 years) had higher HRs than older patients (≥65 years) within the same disease groups. Conclusion: This study suggests the synergistic effect of CKD in DR patients on dementia risk, emphasizing the need of early screening and integrated care for diabetes-related complications. Disclosure N. Song: None. Y. Park: None. M. Moon: None.

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.