年轻脑卒中患者血管壁异常的患病率和血管事件复发的风险。

IF 4.5 3区 医学 Q1 CLINICAL NEUROLOGY
Esther M Boot, Frederick J A Meijer, Sjoert Pegge, Sjan Teeselink, Mijntje Mi Schellekens, Merel S Ekker, Jamie I Verhoeven, Esmée Verburgt, Maikel Immens, Nina Hilkens, Frank-Erik de Leeuw, Anil M Tuladhar
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引用次数: 0

摘要

简介:我们研究了年轻脑卒中患者血管壁病变的患病率和特征及其与复发性血管事件的关系。我们假设有VW病变与血管事件复发的风险增加有关。患者和方法:年龄18-50岁,短暂性脑缺血发作(TIA)或缺血性脑卒中,接受高分辨率3T磁共振成像(HR-MRI)和VW成像的单中心前瞻性研究。我们纳入了10例被诊断为中风模拟症状的对照。HR-MRI扫描结果由两名神经放射学家进行审查,以获取临床信息。随访是通过电话采访进行的。复发性血管事件定义为TIA、脑卒中、心肌梗死、血运重建术或血管性死亡。结果:我们纳入158名参与者(中位年龄:41.5岁,IQR 33.0-46.4);其中75人(47.5%)为女性。其中44例(27.8%)患者有81例VW病变,主要表现为VW增强(74.1%)。86.4%的VW病变位于相应的缺血区域,48.6%的VW病变未出现MRA异常。几乎一半的VW病变出现在罕见原因亚组,而13.6%的“隐源性”亚组显示VW增强。VW病变与血管事件复发风险增加无显著相关(HR 2.2, 95% CI: 0.7-6.6)。结论:四分之一的年轻脑卒中患者存在VW病变,这与血管事件复发的风险增加无关。在所有TOAST类别中都可以看到VW病变,而不是特定于一种中风原因。VW病变在年轻脑卒中患者中的诊断和预后价值有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of vessel wall abnormalities and the risk of recurrent vascular events in young patients with stroke.

Introduction: We examined the prevalence and the characteristics of vessel wall (VW) lesions in young stroke patients and their relation to recurrent vascular events. We hypothesize that having VW lesions is associated with an increased risk on recurrent vascular events.

Patients and methods: Single-center prospective study of participants aged 18-50 years, with a transient ischemic attack (TIA) or ischemic stroke, who underwent high-resolution 3T magnetic resonance imaging (HR-MRI) with VW imaging. We included 10 controls with symptoms diagnosed as stroke mimics. The HR-MRI scans were reviewed by two neuroradiologists blinded for clinical information. Follow-up was conducted via telephone interviews. Recurrent vascular events were defined as TIA, cerebral stroke, myocardial infarctions, revascularization procedures, or vascular death.

Results: We included 158 participants (median age: 41.5 years, IQR 33.0-46.4); 75 (47.5%) of whom were women. Of these, 44 (27.8%) participants had 81 VW lesions, primarily characterized by VW enhancement (74.1%). 86.4% of VW lesions were located in the corresponding ischemic territory, and 48.6% showed no MRA abnormalities. Almost half of the VW lesions were found in the rare causes subgroup, while 13.6% of the "cryptogenic" subgroup showed VW enhancement. VW lesions were not significantly associated with an increased risk of recurrent vascular events (HR 2.2, 95% CI: 0.7-6.6).

Conclusion: One in four young stroke patients have VW lesions, which were not related to an increased risk of recurrent vascular events. VW lesions were seen across all TOAST categories and were not specific to one stroke cause. Further research is needed to investigate the diagnostic and prognostic value of VW lesions in young stroke patients.

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来源期刊
CiteScore
7.50
自引率
6.60%
发文量
102
期刊介绍: Launched in 2016 the European Stroke Journal (ESJ) is the official journal of the European Stroke Organisation (ESO), a professional non-profit organization with over 1,400 individual members, and affiliations to numerous related national and international societies. ESJ covers clinical stroke research from all fields, including clinical trials, epidemiology, primary and secondary prevention, diagnosis, acute and post-acute management, guidelines, translation of experimental findings into clinical practice, rehabilitation, organisation of stroke care, and societal impact. It is open to authors from all relevant medical and health professions. Article types include review articles, original research, protocols, guidelines, editorials and letters to the Editor. Through ESJ, authors and researchers have gained a new platform for the rapid and professional publication of peer reviewed scientific material of the highest standards; publication in ESJ is highly competitive. The journal and its editorial team has developed excellent cooperation with sister organisations such as the World Stroke Organisation and the International Journal of Stroke, and the American Heart Organization/American Stroke Association and the journal Stroke. ESJ is fully peer-reviewed and is a member of the Committee on Publication Ethics (COPE). Issues are published 4 times a year (March, June, September and December) and articles are published OnlineFirst prior to issue publication.
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