Lv Tian, Yixuan Wen, Jingmiao Li, Jiexin Guan, Tao Li, Jun Fan
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However, due to the limited number of relevant studies, the impact of web-based interventions in cancer management remains unclear.</p><p><strong>Objective: </strong>We aimed to determine the efficacy of interventions based on apps, miniprograms, or other web-based tools on the physiological (body pain and fatigue) and psychological (anxiety and depression) states and the quality of life of patients with cancer.</p><p><strong>Methods: </strong>We conducted electronic literature searches in PubMed, Scopus, Web of Science, the Cochrane Library, CINAHL, and EMBASE databases. The search period spanned from the inception of each database to October 15, 2024. Two researchers independently conducted literature retrieval and data extraction. The risk of bias was assessed with the Cochrane risk-of-bias tool, and the quality of evidence was assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). All statistical analyses were performed using Review Manager version 5.4.</p><p><strong>Results: </strong>A total of 36 randomized controlled trials were included. The remote web-based interventions significantly improved the pain intensity (n=14, 39% studies; standardized mean difference [SMD] -0.39, 95% CI -0.64 to -0.14; I<sup>2</sup>=82%; GRADE rating=low) and fatigue status (n=11, 31% studies; SMD -0.52, 95% CI -0.95 to -0.09; I<sup>2</sup>=95%; GRADE rating=low) in patients with cancer. Regarding psychology, the results indicated that the remote web-based interventions significantly improved the anxiety (n=14, 39% studies; SMD -0.60, 95% CI -0.90 to -0.30; I<sup>2</sup>=91%; GRADE rating=low) and depressive state (n=10, 28% studies; SMD -0.36, 95% CI -0.58 to -0.14; I<sup>2</sup>=81%; GRADE rating=low) of patients with cancer. For quality of life, the results showed that the remote web-based interventions had a significant positive impact on the quality of life of patients with cancer (n=26, 72% studies; SMD 0.63, 95% CI 0.39-0.87; I<sup>2</sup>=92%; GRADE rating=low).</p><p><strong>Conclusions: </strong>The remote web-based interventions were effective in reducing the intensity of physiological pain, relieving fatigue, improving depression and anxiety, and improving the quality of life of patients with cancer. However, due to the low certainty of evidence, more rigorous randomized controlled trials are needed to validate these findings further.</p><p><strong>Trial registration: </strong>PROSPERO CRD42024611768; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024611768.</p>","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"13 ","pages":"e71196"},"PeriodicalIF":6.2000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203031/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of Remote Web-Based Interventions on the Physiological and Psychological States of Patients With Cancer: Systematic Review With Meta-Analysis.\",\"authors\":\"Lv Tian, Yixuan Wen, Jingmiao Li, Jiexin Guan, Tao Li, Jun Fan\",\"doi\":\"10.2196/71196\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Patients with cancer may experience physiological and psychological adverse reactions, such as fatigue, pain, anxiety, and depression, which seriously affect their quality of life. Research has shown that remote interventions based on apps or miniprograms may help improve the physiological and mental health of patients with cancer. However, due to the limited number of relevant studies, the impact of web-based interventions in cancer management remains unclear.</p><p><strong>Objective: </strong>We aimed to determine the efficacy of interventions based on apps, miniprograms, or other web-based tools on the physiological (body pain and fatigue) and psychological (anxiety and depression) states and the quality of life of patients with cancer.</p><p><strong>Methods: </strong>We conducted electronic literature searches in PubMed, Scopus, Web of Science, the Cochrane Library, CINAHL, and EMBASE databases. The search period spanned from the inception of each database to October 15, 2024. Two researchers independently conducted literature retrieval and data extraction. The risk of bias was assessed with the Cochrane risk-of-bias tool, and the quality of evidence was assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). All statistical analyses were performed using Review Manager version 5.4.</p><p><strong>Results: </strong>A total of 36 randomized controlled trials were included. The remote web-based interventions significantly improved the pain intensity (n=14, 39% studies; standardized mean difference [SMD] -0.39, 95% CI -0.64 to -0.14; I<sup>2</sup>=82%; GRADE rating=low) and fatigue status (n=11, 31% studies; SMD -0.52, 95% CI -0.95 to -0.09; I<sup>2</sup>=95%; GRADE rating=low) in patients with cancer. 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引用次数: 0
摘要
背景：癌症患者可能会出现生理和心理上的不良反应，如疲劳、疼痛、焦虑、抑郁等，严重影响其生活质量。研究表明，基于应用程序或小程序的远程干预可能有助于改善癌症患者的生理和心理健康。然而，由于相关研究数量有限，基于网络的干预在癌症管理中的影响尚不清楚。目的：我们旨在确定基于应用程序、小程序或其他基于网络的工具的干预措施对癌症患者的生理（身体疼痛和疲劳）和心理（焦虑和抑郁）状态以及生活质量的影响。方法：在PubMed、Scopus、Web of Science、Cochrane Library、CINAHL和EMBASE数据库中进行电子文献检索。搜索周期从每个数据库建立到2024年10月15日。两位研究者独立进行文献检索和数据提取。使用Cochrane风险-偏倚工具评估偏倚风险，根据推荐评估、发展和评价分级（GRADE）评估证据质量。所有的统计分析使用Review Manager版本5.4进行。结果：共纳入36项随机对照试验。远程网络干预显著改善疼痛强度(n=14, 39%的研究；标准化平均差[SMD] -0.39, 95% CI -0.64 ~ -0.14；I2 = 82%;GRADE评分=低)和疲劳状态(n=11, 31%的研究；SMD -0.52, 95% CI -0.95 ~ -0.09；I2 = 95%;GRADE评分=低)。在心理学方面，结果表明远程网络干预显著改善了焦虑(n=14, 39%的研究；SMD -0.60, 95% CI -0.90 ~ -0.30；I2 = 91%;GRADE评分=低)和抑郁状态(n=10, 28%的研究；SMD -0.36, 95% CI -0.58 ~ -0.14；I2 = 81%;GRADE评分=低)。对于生活质量，结果显示远程基于网络的干预对癌症患者的生活质量有显著的积极影响(n= 26,72%的研究；SMD 0.63, 95% ci 0.39-0.87；I2 = 92%;级评级=低)。结论：远程网络干预可有效减轻癌症患者生理性疼痛强度、缓解疲劳、改善抑郁和焦虑，提高患者生活质量。然而，由于证据的低确定性，需要更严格的随机对照试验来进一步验证这些发现。试验注册：PROSPERO CRD42024611768；https://www.crd.york.ac.uk/PROSPERO/view/CRD42024611768。
Effects of Remote Web-Based Interventions on the Physiological and Psychological States of Patients With Cancer: Systematic Review With Meta-Analysis.
Background: Patients with cancer may experience physiological and psychological adverse reactions, such as fatigue, pain, anxiety, and depression, which seriously affect their quality of life. Research has shown that remote interventions based on apps or miniprograms may help improve the physiological and mental health of patients with cancer. However, due to the limited number of relevant studies, the impact of web-based interventions in cancer management remains unclear.
Objective: We aimed to determine the efficacy of interventions based on apps, miniprograms, or other web-based tools on the physiological (body pain and fatigue) and psychological (anxiety and depression) states and the quality of life of patients with cancer.
Methods: We conducted electronic literature searches in PubMed, Scopus, Web of Science, the Cochrane Library, CINAHL, and EMBASE databases. The search period spanned from the inception of each database to October 15, 2024. Two researchers independently conducted literature retrieval and data extraction. The risk of bias was assessed with the Cochrane risk-of-bias tool, and the quality of evidence was assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). All statistical analyses were performed using Review Manager version 5.4.
Results: A total of 36 randomized controlled trials were included. The remote web-based interventions significantly improved the pain intensity (n=14, 39% studies; standardized mean difference [SMD] -0.39, 95% CI -0.64 to -0.14; I2=82%; GRADE rating=low) and fatigue status (n=11, 31% studies; SMD -0.52, 95% CI -0.95 to -0.09; I2=95%; GRADE rating=low) in patients with cancer. Regarding psychology, the results indicated that the remote web-based interventions significantly improved the anxiety (n=14, 39% studies; SMD -0.60, 95% CI -0.90 to -0.30; I2=91%; GRADE rating=low) and depressive state (n=10, 28% studies; SMD -0.36, 95% CI -0.58 to -0.14; I2=81%; GRADE rating=low) of patients with cancer. For quality of life, the results showed that the remote web-based interventions had a significant positive impact on the quality of life of patients with cancer (n=26, 72% studies; SMD 0.63, 95% CI 0.39-0.87; I2=92%; GRADE rating=low).
Conclusions: The remote web-based interventions were effective in reducing the intensity of physiological pain, relieving fatigue, improving depression and anxiety, and improving the quality of life of patients with cancer. However, due to the low certainty of evidence, more rigorous randomized controlled trials are needed to validate these findings further.
期刊介绍：
JMIR mHealth and uHealth (JMU, ISSN 2291-5222) is a spin-off journal of JMIR, the leading eHealth journal (Impact Factor 2016: 5.175). JMIR mHealth and uHealth is indexed in PubMed, PubMed Central, and Science Citation Index Expanded (SCIE), and in June 2017 received a stunning inaugural Impact Factor of 4.636.
The journal focusses on health and biomedical applications in mobile and tablet computing, pervasive and ubiquitous computing, wearable computing and domotics.
JMIR mHealth and uHealth publishes since 2013 and was the first mhealth journal in Pubmed. It publishes even faster and has a broader scope with including papers which are more technical or more formative/developmental than what would be published in the Journal of Medical Internet Research.
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