{"title":"低剂量甲醛暴露对健康的影响：职业环境中的横断面研究。","authors":"Hao-Yi Fan, Jhe-Ping Lin, Ting-An Yang, Yu-Chung Tsao","doi":"10.13075/ijomeh.1896.02503","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the health effects of low-dose formaldehyde exposure in occupational settings, focusing on dermatological and respiratory symptoms and the influence of work tenure.</p><p><strong>Material and methods: </strong>A cross-sectional study was conducted on 414 workers undergoing annual health check-ups at a medical center in Taiwan with 242 individuals categorized as exposed (high exposure [N = 57], low exposure [N = 185]) and 172 as controls. Formaldehyde exposure was assessed through environmental monitoring, with all exposure levels <10% of the permissible exposure limits. Self-reported clinical symptoms, complete blood count (CBC) parameters, and pulmonary function were assessed. Logistic regression analysis was performed to assess exposure-related health effects, adjusting for potential confounders. Tenure was analyzed as both a continuous and categorical variable to assess its impact on health outcomes.</p><p><strong>Results: </strong>The exposure group reported significantly higher rates of irritationrelated symptoms (9.5% vs. 0.6%, p = 0.009) and skin symptoms (1.7% vs. 0%, p < 0.001) compared to controls. After adjusting for confounders, allergic rhinitis (OR = 16.78, 95% CI: 4.00-70.55, p < 0.001) and allergic dermatitis (OR = 18.83, 95% CI: 2.52-140.56, p = 0.004) remained significantly associated with formaldehyde exposure. No significant differences were found in CBC parameters or pulmonary function between groups.</p><p><strong>Conclusions: </strong>Even at low exposure levels, formaldehyde was associated with an increased risk of allergic conditions and irritation-related symptoms. While pulmonary function remained unchanged, the higher prevalence of allergic rhinitis and dermatitis suggests potential immune sensitization. These findings emphasize the importance of workplace exposure monitoring and preventive measures. Future longitudinal studies incorporating biomarkers are needed to clarify causal relationships and refine occupational health policies. Int J Occup Med Environ Health. 2025;38(3):236-248.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":" ","pages":"236-248"},"PeriodicalIF":1.4000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Health effects of low-dose formaldehyde exposure: a cross-sectional study in occupational settings.\",\"authors\":\"Hao-Yi Fan, Jhe-Ping Lin, Ting-An Yang, Yu-Chung Tsao\",\"doi\":\"10.13075/ijomeh.1896.02503\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To evaluate the health effects of low-dose formaldehyde exposure in occupational settings, focusing on dermatological and respiratory symptoms and the influence of work tenure.</p><p><strong>Material and methods: </strong>A cross-sectional study was conducted on 414 workers undergoing annual health check-ups at a medical center in Taiwan with 242 individuals categorized as exposed (high exposure [N = 57], low exposure [N = 185]) and 172 as controls. Formaldehyde exposure was assessed through environmental monitoring, with all exposure levels <10% of the permissible exposure limits. Self-reported clinical symptoms, complete blood count (CBC) parameters, and pulmonary function were assessed. Logistic regression analysis was performed to assess exposure-related health effects, adjusting for potential confounders. Tenure was analyzed as both a continuous and categorical variable to assess its impact on health outcomes.</p><p><strong>Results: </strong>The exposure group reported significantly higher rates of irritationrelated symptoms (9.5% vs. 0.6%, p = 0.009) and skin symptoms (1.7% vs. 0%, p < 0.001) compared to controls. After adjusting for confounders, allergic rhinitis (OR = 16.78, 95% CI: 4.00-70.55, p < 0.001) and allergic dermatitis (OR = 18.83, 95% CI: 2.52-140.56, p = 0.004) remained significantly associated with formaldehyde exposure. No significant differences were found in CBC parameters or pulmonary function between groups.</p><p><strong>Conclusions: </strong>Even at low exposure levels, formaldehyde was associated with an increased risk of allergic conditions and irritation-related symptoms. While pulmonary function remained unchanged, the higher prevalence of allergic rhinitis and dermatitis suggests potential immune sensitization. These findings emphasize the importance of workplace exposure monitoring and preventive measures. Future longitudinal studies incorporating biomarkers are needed to clarify causal relationships and refine occupational health policies. Int J Occup Med Environ Health. 2025;38(3):236-248.</p>\",\"PeriodicalId\":14173,\"journal\":{\"name\":\"International journal of occupational medicine and environmental health\",\"volume\":\" \",\"pages\":\"236-248\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of occupational medicine and environmental health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.13075/ijomeh.1896.02503\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of occupational medicine and environmental health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.13075/ijomeh.1896.02503","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/13 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Health effects of low-dose formaldehyde exposure: a cross-sectional study in occupational settings.
Objectives: To evaluate the health effects of low-dose formaldehyde exposure in occupational settings, focusing on dermatological and respiratory symptoms and the influence of work tenure.
Material and methods: A cross-sectional study was conducted on 414 workers undergoing annual health check-ups at a medical center in Taiwan with 242 individuals categorized as exposed (high exposure [N = 57], low exposure [N = 185]) and 172 as controls. Formaldehyde exposure was assessed through environmental monitoring, with all exposure levels <10% of the permissible exposure limits. Self-reported clinical symptoms, complete blood count (CBC) parameters, and pulmonary function were assessed. Logistic regression analysis was performed to assess exposure-related health effects, adjusting for potential confounders. Tenure was analyzed as both a continuous and categorical variable to assess its impact on health outcomes.
Results: The exposure group reported significantly higher rates of irritationrelated symptoms (9.5% vs. 0.6%, p = 0.009) and skin symptoms (1.7% vs. 0%, p < 0.001) compared to controls. After adjusting for confounders, allergic rhinitis (OR = 16.78, 95% CI: 4.00-70.55, p < 0.001) and allergic dermatitis (OR = 18.83, 95% CI: 2.52-140.56, p = 0.004) remained significantly associated with formaldehyde exposure. No significant differences were found in CBC parameters or pulmonary function between groups.
Conclusions: Even at low exposure levels, formaldehyde was associated with an increased risk of allergic conditions and irritation-related symptoms. While pulmonary function remained unchanged, the higher prevalence of allergic rhinitis and dermatitis suggests potential immune sensitization. These findings emphasize the importance of workplace exposure monitoring and preventive measures. Future longitudinal studies incorporating biomarkers are needed to clarify causal relationships and refine occupational health policies. Int J Occup Med Environ Health. 2025;38(3):236-248.
期刊介绍：
The Journal is dedicated to present the contemporary research in occupational and environmental health from all over the world. It publishes works concerning: occupational and environmental: medicine, epidemiology, hygiene and toxicology; work physiology and ergonomics, musculoskeletal problems; psychosocial factors at work, work-related mental problems, aging, work ability and return to work; working hours, shift work; reproductive factors and endocrine disruptors; radiation, ionizing and non-ionizing health effects; agricultural hazards; work safety and injury and occupational health service; climate change and its effects on health; omics, genetics and epigenetics in occupational and environmental health; health effects of exposure to nanoparticles and nanotechnology products; human biomarkers in occupational and environmental health, intervention studies, clinical sciences’ achievements with potential to improve occupational and environmental health.
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