对称苯和芴酮的发散合成。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-12 DOI:10.1021/acs.orglett.5c01804

Yingjian Gong, Li Li, Qian Wu, Tu Zeng, Yi Tian, Xingcan Zhang, Jingpeng Han* and Baosheng Li*,

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引用次数: 0

摘要

苯环是具有重要生物学意义的化合物和功能材料中普遍存在的核心结构。这促使了苯衍生物合成的创新方法的发展。我们提出了一种不同的合成策略来获得1,2-二呋喃取代的对称苯和高功能化芴酮。在这种方法中，所有的芳香族核心都是通过铜介导的二聚体环芳香化级联序列产生的，利用现成的二乙烯基酮。该协议不仅提供了一种合成对称芳烃的替代方法，而且为呋喃氧化转化为合成有价值的物质提供了框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Divergent Synthesis of Symmetric Benzenes and Fluorenones

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Divergent Synthesis of Symmetric Benzenes and Fluorenones

The benzene ring is a prevalent core structure in both biologically significant compounds and functional materials. This prompts the development of innovative methods for synthesizing benzene derivatives. We present a divergent synthetic strategy for accessing 1,2-difuryl-substituted symmetrical benzene and highly functionalized fluorenones. In this approach, all aromatic cores are generated through a copper-mediated dimeric cycloaromatization cascade sequence, utilizing readily available dienynyl ketones. This protocol not only offers an alternative method for synthesizing symmetrical aromatics but also provides a framework for the oxidative transformation of furans into synthetically valuable substances.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.