硫醚与伯胺的化学选择性电化学偶联制备亚砜亚胺和亚砜亚胺

IF 15.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-06-12 DOI:10.1021/jacs.5c04012

Sukwoo Lee, Jonas Rein, Evan A. Weingarten and Song Lin*,

引用次数: 0

摘要

我们报道了硫醚与伯烷基胺的电氧化偶联，得到了结构多样的亚砜亚胺和亚砜亚胺，包括非常规的异肽。循环伏安法和控制实验表明，调节反应物和产物的质子化状态是实现化学选择性氧化的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemoselective Electrochemical Coupling of Thioethers and Primary Amines for Accessing Sulfilimines and Sulfoximines

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Chemoselective Electrochemical Coupling of Thioethers and Primary Amines for Accessing Sulfilimines and Sulfoximines

We report the electrooxidative coupling of thioethers with primary alkylamines, furnishing structurally diverse sulfilimines and sulfoximines including unconventional isopeptides. Cyclic voltammetry and control experiments revealed that modulating the protonation states of reactants and products is key to achieving chemoselective oxidation.

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.