韩国人全血中COVID-19诱导的动态可逆转录组年龄变化

IF 3.9 3区医学 Q2 CELL BIOLOGY

Aging-Us Pub Date : 2025-06-10 DOI:10.18632/aging.206270

Kyungwhan An, Yoonsung Kwon, Jihun Bhak, Hyojung Ryu, Sungwon Jeon, Dougu Nam, Jong Bhak

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引用次数: 0

摘要

我们利用440名健康个体的全血样本，开发了首个针对朝鲜族的全基因组转录组钟来预测实足年龄。我们的分析显示，在COVID-19患者体内平衡破坏期间，年龄明显加速，最高可达21.31岁，恢复后恢复到基线水平。这些发现强调了血液转录组动态跟踪感染期间年龄相关炎症反应可逆变化的能力。我们的研究强调了抗衰老干预在控制传染病方面的潜力。

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Dynamic and reversible transcriptomic age shifts induced by COVID-19 in Korean whole blood.

We developed the first genome-wide transcriptomic clock specific to Korean ethnicity to predict chronological age using whole blood samples from 440 healthy individuals. Our analysis revealed profound age acceleration - up to 21.31 years - during homeostatic disruption in COVID-19 patients, which reverted to baseline upon recovery. These findings highlight the ability of the blood transcriptome to dynamically track reversible changes in age-associated inflammatory responses during infections. Our study underscores the potential of anti-aging interventions in managing infectious diseases.

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