澳大利亚脑膜炎球菌监测规划年度报告,2015年。

IF 1.6 Q4 INFECTIOUS DISEASES
Monica M Lahra, Rodney P Enriquez
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引用次数: 0

摘要

2015年,澳大利亚国家奈瑟菌网络分析了174例实验室确诊的侵袭性脑膜炎球菌病病例。这一数字高于2013年和2014年报告的数字,2013年和2014年分别是自1994年澳大利亚脑膜炎球菌监测规划启动以来报告的最低和第二低的总数。可能的和实验室确认的侵袭性脑膜炎球菌病(IMD)在澳大利亚是必须报告的。2015年,向国家法定疾病监测系统报告了182例IMD病例,再次高于2013年和2014年,2013年和2014年分别是该系统记录的IMD病例总数最低和第二低的年份。168/174例(97%)实验室确诊的IMD病例能够确定脑膜炎球菌血清分型。其中,64.2%(108例)为血清B组感染,是2003年以来报告的最低水平。此外,血清C组IMD的病例数和比例(1.2%,2例)是迄今为止报道的最低的。相比之下,2015年在澳大利亚,血清W型IMD的数量和比例明显增加(21.4%,36例),血清Y型IMD增加(13.1%,22例)。自1994年澳大利亚脑膜炎球菌监测方案开始以来,由W和Y血清群引起的IMD病例的数量和比例是最高的。174例IMD中有140例可获得分子分型结果。在31株能够进行基因分型的W型IMD血清菌株中,25/31(81%)为序列型(ST)-11,其porA抗原编码基因型为P1.5,2,与2009年以来在英国和南美洲流行的高毒性W型血清菌株基因型相同。2015年,澳大利亚流行的最常见的血清B组孔a基因型为p1.7 -2,4。原发性IMD年龄高峰出现在45岁及以上的成年人中,这是AMSP首次注意到这一点,而继发性疾病高峰出现在4岁及以下的人群和青少年(15-19岁)中。血清型B病例在所有辖区和年龄组中都占多数,但45岁或以上的人群中,血清型W和Y占多数。所有IMD分离株均对头孢曲松和环丙沙星敏感。一个分离株对利福平耐药。4株对青霉素耐药。86%的分离株对青霉素的敏感性降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Australian Meningococcal Surveillance Programme annual report, 2015.

In 2015, there were 174 laboratory-confirmed cases of invasive meningococcal disease analysed by the Australian National Neisseria Network. This number was higher than that reported in 2013 and 2014, which were the lowest and second-lowest totals reported, respectively, since inception of the Australian Meningococcal Surveillance Programme in 1994. Probable and laboratory confirmed invasive meningococcal disease (IMD) is notifiable in Australia. There were 182 IMD cases notified to the National Notifiable Diseases Surveillance System in 2015, again, higher than in 2013 and 2014, which were the lowest and second-lowest totals of IMD cases recorded, respectively, by this system. Meningococcal serogrouping was able to be determined for 168/174 (97%) laboratory confirmed IMD cases. Of these, 64.2% (108 cases) were serogroup B infections, the lowest reported since 2003. Further, the number and proportion of cases of serogroup C IMD, (1.2%, 2 cases), was the lowest yet reported. By contrast, in 2015 in Australia, there was a marked increase in the number and proportion of serogroup W IMD (21.4%, 36 cases), and an increase in serogroup Y IMD (13.1%, 22 cases). The number and proportion of IMD cases caused by serogroups W and Y was the highest reported since the inception of the Australian Meningococcal Surveillance Programme in 1994. Molecular typing results were available for 140 of the 174 IMD cases. Of the 31 serogroup W IMD strains that were able to be genotyped, 25/31 (81%) were sequence type (ST)-11, and have the porA antigen encoding gene type P1.5,2, the same genotype as the hypervirulent serogroup W strain of that has been circulating in the United Kingdom and South America since 2009. In 2015, the most common serogroup B porA genotype circulating in Australia was P1.7-2,4. The primary IMD age peak was observed in adults aged 45 years or more, which was the first time that this was noted by the AMSP, whilst secondary disease peaks were observed in those aged 4 years or less, and in adolescents (15-19 years). Serogroup B cases predominated in all jurisdictions and age groups, except for those aged 45 years or over where serogroups W and Y predominated. All IMD isolates tested were susceptible to ceftriaxone and ciprofloxacin. One isolate was resistant to rifampicin. Four isolates were resistant to penicillin. Decreased susceptibility to penicillin was observed in 86% of isolates.

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来源期刊
Communicable Diseases Intelligence
Communicable Diseases Intelligence INFECTIOUS DISEASES-
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