肠-脑-免疫轴对心理健康和疾病的影响。

IF 3.5 2区 生物学 Q3 CELL BIOLOGY
Hadi Nasiri, Zahra Valedkarimi, Morteza Akbari
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引用次数: 0

摘要

肠-脑-免疫轴在胃肠道、免疫系统和中枢神经系统之间表现出复杂的相互作用,显著影响心理健康。维持免疫稳态和大脑功能依赖于肠道细菌,肠道细菌由于其不同的微生物种群而至关重要。沿着这条轴,通过免疫反应、微生物代谢物和大脑通路进行交流。精神健康问题,如压力、悲伤、自闭症谱系障碍(ASD)和精神分裂症,都与生态失调和炎症有关。通过益生菌、益生元、饮食改变以及药物和非药物治疗等治疗方法,恢复微生物平衡和增强心理健康结果显示出希望。未来的研究应集中在阐明肠-脑-免疫轴机制,创造个性化的治疗方法,并将结果应用于临床。通过解决其根本原因并鼓励总体健康,这种综合方法为治疗心理健康问题提供了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gut-brain-immune axis implications for mental health and disease.

Significantly affecting mental health, the gut-brain-immune axis shows a complicated interaction between the gastrointestinal tract, immune system, and central nervous system. Maintaining immunological homeostasis and brain function depends on gut bacteria, which are crucial due to their varied microbial populations. Along this axis, communication takes place via immunological responses, microbial metabolites, and brain pathways. Mental health issues like stress, sadness, autism spectrum disorders (ASD), and schizophrenia are linked to dysbiosis and inflammation. Restoring microbial balance and enhancing mental health outcomes show promise from therapeutic approaches, including probiotics, prebiotics, dietary changes, and pharmaceutical and non-pharmacological therapies. Future studies should concentrate on clarifying the gut-brain-immune axis mechanics, creating individualized treatments, and applying results into clinical use. By tackling their underlying causes and encouraging general well-being, this combined approach presents fresh paths for treating mental health problems.

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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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