δ-生育三烯醇通过抑制pd - l1介导的促癌信号使乳腺癌和前列腺癌细胞对紫杉醇有增强作用

IF 3.3 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zhenou Sun, Xuan Ma, Jiaxuan Li, Lihong Fan, Chong Zhao, Shutao Yin, Hongbo Hu
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引用次数: 0

摘要

维生素E既可以起到预防癌症的作用,也可以提高化疗药物对多种癌症的治疗效果。大量证据表明,维生素E的癌症预防作用是形式依赖的;然而,尚不清楚其化学增敏作用是否也受其形式的影响。本研究的目的是研究八种天然形式的维生素E是否对癌症化疗药物产生不同的增敏作用,并探讨维生素E的增敏作用是否与其对程序性细胞死亡配体1 (PD-L1)信号传导的抑制作用有关。我们以紫杉醇为代表的治疗药物,以乳腺癌/前列腺癌为代表的癌症类型,对8种维生素E形式的化疗增敏效果进行了比较评价。结果表明,维生素E对化疗药物的增敏作用也是形式依赖的,δ-生育三烯醇(δ-T3)是使乳腺癌和前列腺癌细胞对紫杉醇增敏最有效的一种,其机制与其抑制pd - l1介导的促瘤信号的能力有关。研究结果为进一步了解维生素E的增敏作用及其机制提供了新的思路,并支持δ-T3是8种形式中紫杉烷增强剂的最佳候选。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
δ-Tocotrienol Potentiates Breast and Prostate Cancer Cells to Paclitaxel via Suppressing PD-L1-Mediated Cancer-Promoting Signaling

Vitamin E can exert either a cancer preventive effect or improve the therapeutic efficacy of chemotherapeutic drugs against multiple types of cancer. Ample evidence suggests that the cancer preventive activity of vitamin E is form-dependent; however, it is not clear whether its chemosensitization effect is also influenced by its forms. The objectives of this study were to investigate whether the eight natural forms of vitamin E produced differential sensitization effects on cancer chemotherapeutic drugs and to address whether the chemosensitization effect of vitamin E was associated with its inhibitory effect on programmed cell death ligand 1 (PD-L1) signaling. We carried out a comparative evaluation of the chemosensitization effect of eight vitamin E forms using paclitaxel as a representative therapeutic drug and breast/prostate cancer as the representative types of cancer. Results showed that the sensitization effect of vitamin E on chemotherapeutic drugs was also form-dependent, with δ-tocotrienol (δ-T3) as the most effective one for sensitizing breast and prostate cancer cells to paclitaxel, mechanistically associated with its ability to suppress PD-L1-mediated tumor-promoting signaling. The findings provided novel insights into understanding the sensitization effect of vitamin E and its related mechanisms and support that δ-T3 is the best candidate as an enhancer of taxanes among the eight forms.

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来源期刊
Chemical Biology & Drug Design
Chemical Biology & Drug Design 医学-生化与分子生物学
CiteScore
5.10
自引率
3.30%
发文量
164
审稿时长
4.4 months
期刊介绍: Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design. It is the aim of Chemical Biology & Drug Design to capture significant research and drug discovery that highlights new concepts, insight and new findings within the scope of chemical biology and drug design.
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