Ji Chen, Fan Zhang, Yangyuxi Chen, Yingqing Lu, Xinxin Liu, Yuanzhang Tang, Fengrui Yang
{"title":"circ_0012856在调节糖尿病周围神经病变分子通路中的作用","authors":"Ji Chen, Fan Zhang, Yangyuxi Chen, Yingqing Lu, Xinxin Liu, Yuanzhang Tang, Fengrui Yang","doi":"10.1002/ccs3.70019","DOIUrl":null,"url":null,"abstract":"<p>Diabetic peripheral neuropathy (DPN), a common complication of diabetes mellitus, involves complex molecular pathways and the ceRNA regulatory network. Integration of diabetes-related circRNA datasets identified circ_0012856 as pivotal via least absolute shrinkage and selection operator and support vector machine recursive feature elimination algorithms. Functional enrichment analyses elucidated its involvement in DPN pathogenesis. In vitro studies showed circ_0012856 regulating EZH2 and STAT3 expressions, inhibiting autophagy, and promoting microglial M1 polarization. In vivo, experiments revealed silencing circ_0012856 alleviating DPN symptoms in diabetic mice. Overall, circ_0012856 acts as a miR-124 sponge, affecting key pathways in DPN progression and providing potential therapeutic targets.</p>","PeriodicalId":15226,"journal":{"name":"Journal of Cell Communication and Signaling","volume":"19 2","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccs3.70019","citationCount":"0","resultStr":"{\"title\":\"Role of circ_0012856 in modulating molecular pathways of diabetic peripheral neuropathy\",\"authors\":\"Ji Chen, Fan Zhang, Yangyuxi Chen, Yingqing Lu, Xinxin Liu, Yuanzhang Tang, Fengrui Yang\",\"doi\":\"10.1002/ccs3.70019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Diabetic peripheral neuropathy (DPN), a common complication of diabetes mellitus, involves complex molecular pathways and the ceRNA regulatory network. Integration of diabetes-related circRNA datasets identified circ_0012856 as pivotal via least absolute shrinkage and selection operator and support vector machine recursive feature elimination algorithms. Functional enrichment analyses elucidated its involvement in DPN pathogenesis. In vitro studies showed circ_0012856 regulating EZH2 and STAT3 expressions, inhibiting autophagy, and promoting microglial M1 polarization. In vivo, experiments revealed silencing circ_0012856 alleviating DPN symptoms in diabetic mice. Overall, circ_0012856 acts as a miR-124 sponge, affecting key pathways in DPN progression and providing potential therapeutic targets.</p>\",\"PeriodicalId\":15226,\"journal\":{\"name\":\"Journal of Cell Communication and Signaling\",\"volume\":\"19 2\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccs3.70019\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cell Communication and Signaling\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ccs3.70019\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cell Communication and Signaling","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ccs3.70019","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Role of circ_0012856 in modulating molecular pathways of diabetic peripheral neuropathy
Diabetic peripheral neuropathy (DPN), a common complication of diabetes mellitus, involves complex molecular pathways and the ceRNA regulatory network. Integration of diabetes-related circRNA datasets identified circ_0012856 as pivotal via least absolute shrinkage and selection operator and support vector machine recursive feature elimination algorithms. Functional enrichment analyses elucidated its involvement in DPN pathogenesis. In vitro studies showed circ_0012856 regulating EZH2 and STAT3 expressions, inhibiting autophagy, and promoting microglial M1 polarization. In vivo, experiments revealed silencing circ_0012856 alleviating DPN symptoms in diabetic mice. Overall, circ_0012856 acts as a miR-124 sponge, affecting key pathways in DPN progression and providing potential therapeutic targets.
期刊介绍：
The Journal of Cell Communication and Signaling provides a forum for fundamental and translational research. In particular, it publishes papers discussing intercellular and intracellular signaling pathways that are particularly important to understand how cells interact with each other and with the surrounding environment, and how cellular behavior contributes to pathological states. JCCS encourages the submission of research manuscripts, timely reviews and short commentaries discussing recent publications, key developments and controversies.
Research manuscripts can be published under two different sections :
In the Pathology and Translational Research Section (Section Editor Andrew Leask) , manuscripts report original research dealing with celllular aspects of normal and pathological signaling and communication, with a particular interest in translational research.
In the Molecular Signaling Section (Section Editor Satoshi Kubota) manuscripts report original signaling research performed at molecular levels with a particular interest in the functions of intracellular and membrane components involved in cell signaling.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
