基于邻苯二甲酸酯桥接剂的高效水溶性银(I)配位聚合物的构建：x射线结构、抗癌和抗菌评价

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-06-07 DOI:10.1016/j.ica.2025.122810

Mostafa A. El-Naggar , Morsy A.M. Abu-Youssef , Matti Haukka , Assem Barakat , Ayman El-Faham , Saied M. Soliman , Amal Yousri

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引用次数: 0

摘要

采用自组装技术构建了两种新型的银(I)-邻苯二甲酸酯与吡嗪酰胺（PZA）或3-氰吡啶（3CNPy）聚合物配合物。通过单晶x射线衍射（SCX-RD）、红外光谱（FTIR）和核磁共振光谱（NMR）以及元素分析分析了配合物的结构。[Ag (PZA) (HPhth)] n;1（其中HPhth是邻苯二甲酸氢基团）通过邻苯二甲酸酯和PZA桥呈二维聚合物结构。金属中心在[Ag(3CNPy)2(HPhth)]n；2被两个单齿3CNPy分子和两个桥接邻苯二甲酸基团包围，形成一维配位聚合物。两个配合物的τ4值均为0.6，表明Ag(I)具有高度畸变的四面体配位几何。通过Hirshfeld表面分析，1和2在其dnorm图中分别出现了百分比为8.1和2.4%的AgO键对应的红色斑块，证明了它们的聚合物特征。复合物1和2对肺癌（IC50分别为4.87±0.48和6.48±0.64 μM）和乳腺癌（IC50分别为2.98±0.30和5.47±0.48 μM）具有良好的细胞毒性。这种显著的抗癌活性优于抗癌药物顺铂（A-549和MCF-7的IC50分别为24.91±2.29 μM和15.24±1.76 μM）。这两种复合物的SI都达到6.0，被认为是安全的抗癌药物。另外，1和2对枯草芽孢杆菌具有广谱抗菌活性，其中2对枯草芽孢杆菌具有较强的抗菌作用，MIC = 9.7 μg/mL。

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Construction of potent water-soluble Ag(I) coordination polymers based on bridging phthalate linker: X-ray structure, anticancer, and antimicrobial evaluation

Two novel polymeric Ag(I)-phthalate complexes with pyrazinamide (PZA) or 3-cyanopyridine (3CNPy) were constructed using self-assembly technique. The complexes' structure was analyzed by single crystal X-ray diffraction (SCX-RD), FTIR, and NMR spectra, in addition to elemental analysis. [Ag(PZA)(HPhth)]_n; 1 (where HPhth is hydrogen phthalate group) exhibits two-dimensional polymeric structure via phthalate and PZA bridges. The metal center in [Ag(3CNPy)₂(HPhth)]_n; 2 is surrounded by two monodentate 3CNPy molecules and two bridging phthalate groups giving rise to a 1D coordination polymer. Both complexes have τ₄ value of 0.6 indicating a tetra-coordinated Ag(I) with a highly distorted tetrahedral coordination geometry. Using Hirshfeld surface analysis, the polymeric character of 1 and 2 was demonstrated by the red patches in their d_norm maps corresponding to AgO bonds with percentages of 8.1 and 2.4%, respectively. Complexes 1 and 2 display promising cytotoxicity against lung (IC₅₀ = 4.87 ± 0.48 and 6.48 ± 0.64 μM, respectively) and breast (IC₅₀ = 2.98 ± 0.30 and 5.47 ± 0.48 μM, respectively) carcinoma. This remarkable anticancer activity is better than the anticancer drug cis-platin (IC₅₀ = 24.91 ± 2.29 and 15.24 ± 1.76 μM for A-549 and MCF-7, respectively). With SI up to 6.0, both complexes are considered as safe anticancer treatments. In addition, 1 and 2 show wide-spectrum antimicrobial activities where 2 shows potent antibacterial action against B. subtilis with MIC = 9.7 μg/mL.

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.