急性脑损伤的生物标志物。

IF 2.1
Current opinion in anaesthesiology Pub Date : 2025-10-01 Epub Date: 2025-05-26 DOI:10.1097/ACO.0000000000001532
Katarzyna Prus, Michał Sekuła, Federico Bilotta
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引用次数: 0

摘要

回顾的目的:急性脑损伤是世界范围内发病和致残的主要原因。最近,我们观察到神经影像学的重大进展,这导致了放射诊断的改进;然而,中枢神经系统(CNS)损伤的实验室生物标志物仍然不是常规检查的一部分。最近发现:许多研究提出了潜在的急性脑损伤生物标志物候选物。新的数据将众所周知的中枢神经系统衍生蛋白和酶的应用扩展到急性缺血性卒中、脑出血和蛛网膜下腔出血患者。对microRNA (miRNA)谱分析的兴趣日益浓厚,在临床实践中作为中枢神经系统损伤的生物标志物,其可能的用途带来了令人鼓舞的结果。炎症标志物领域的新数据也被报道——无论是经过充分研究的还是新提出的药物,如生长分化因子15,都显示出在创伤性脑损伤后预测中有希望的前景。更多的研究人员提出联合生物标志物测试小组,包括蛋白质、miRNA和炎症参数,以提高评估的敏感性和特异性。摘要:本综述旨在介绍急性脑损伤生物标志物的最新发现,这些生物标志物可用于神经危重症患者的管理。研究人员报告了新的潜在中枢神经系统损伤生物标志物候选物的数据,这些候选物仍需在大型随机试验中进行验证和标准化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomarkers of acute brain injury.

Purpose of the review: Acute brain injuries are the leading cause of morbidity and disability worldwide. Lately, we have observed significant advances in neuroimaging, which have resulted in improved radiological diagnostics; however, laboratory biomarkers of central nervous system (CNS) injury are still not part of routine workup.

Recent findings: Numerous studies proposed potential acute brain injury biomarker candidates. New data extend the use of well-known CNS-derived proteins and enzymes to acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage patients. The growing interest in microRNA (miRNA) profiling brings encouraging results for its possible utility as a biomarker of CNS injury in clinical practice. New data are also reported in the area of inflammatory markers - both well-studied and new proposed agents, such as growth differentiation factor 15, demonstrate promising perspectives to be used in prognostication following traumatic brain injury. More researchers propose combined biomarker test panels including proteins, miRNA, and inflammatory parameters, to increase the sensitivity and specificity of assessments.

Summary: This review aimed to present recent findings on acute brain injury biomarkers that could be implemented in the management of neurocritical patients. Researchers report data on new potential CNS injury biomarker candidates that must still be validated and standardized in large randomized trials.

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